Compounds and methods for treating candidiasis and aspergillus infections
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.
1. A method of killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having oral or disseminated candidiasis or an aspergillus infection comprising contacting the Candida or Aspergillus species with or administering to the mammal in need thereof an effective amount of a compound of Formula IV:
wherein:
R 1 and R 2 are, independently, —C(═NH)NH 2 , —(CH 2 ) n NH 2 , or —(CH 2 ) n NC(═NH)NH 2 , where n is 2, 3, or 4;
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 wherein R 1 and R 2 are, independently, —C(═NH)NH 2 , —(CH 2 ) n NH 2 , or —(CH 2 ) n NC(═NH)NH 2 , where n is 2 or 3.
3. The method of claim 1 wherein R 1 and R 2 are, independently, —C(═NH)NH 2 or —(CH 2 ) n NH 2 , where n is 2 or 3.
4. The method of claim 1 wherein the compound is:
or a pharmaceutically acceptable salt thereof.