Compositions comprising fibrous polypeptides and polysaccharides
Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.
1. A method of generating an isolated composite comprising resilin and cellulose, the method comprising contacting said resilin with said cellulose under conditions which allow binding between said resilin and said cellulose to generate the isolated composite comprising resilin and said cellulose.
2. The method of claim 1 , further comprising crosslinking said composite following said contacting.
3. The method of claim 2 , wherein said crosslinking is affected by a method selected from the group consisting of photochemical crosslinking, enzymatic crosslinking, chemical crosslinking and physical crosslinking.
4. The method of claim 2 , further comprising coating said composite with an additional fibrous polypeptide, said coating being effected following said crosslinking of the composite.
5. The method claim 1 , further comprising binding said resilin with an additional fibrous polypeptide prior to said contacting.
6. The method of claim 4 , wherein said additional fibrous polypeptide is selected from the group consisting of a mussel byssus protein, spider silk protein, collagen, elastin and fibronectin and fragments thereof.