Composite materials
This application discloses a composite material comprising one or more silk elements in an acrylic or cross-linked protein matrix. The silk elements are made from the group of silk elements consisting of domestic silkworm silk, wild silkworm silk, spider dragline silk, and filaments spun from recombinant silk protein or protein analogs. The composite material is particularly useful for use in-surgical-implants.
1. A surgically implantable device comprising a biocompatible composite material, wherein;
said biocompatible composite material comprises one or more silk elements,
said silk elements comprise at least one silk protein selected from the group of proteins consisting of wild silkworm silk proteins, recombinant wild silkworm silk proteins, and analogues thereof,
the protein sequence of said at least one silk protein comprises at least eight repeats of the triplet RGD, and
said one or more silk elements are embedded in a cross-linked fibroin or cross-linked casein protein matrix.
2. The surgically implantable device of claim 1 , wherein at least some of the at least eight repeats of the triplet RGD are located immediately adjacent to turns or predicted turns of a structure of the silkworm silk protein.
3. The surgically implantable device of claim 1 , wherein said at least one silk protein is from a silk worm selected from the group of silkworms consisting of Antheraea yamamai and Antheraea militta.
4. The surgically implantable device of claim 1 , wherein the device is substantially cylindrical and the one or more silk elements are arranged longitudinally on a surface of the surgically implantable device.
5. The surgically implantable device of claim 1 , wherein the device is substantially cylindrical and the one or more silk elements are arranged in a helical manner on the surface of the device.
6. The surgically implantable device of claim 1 , wherein the device is substantially cylindrical and the one or more silk elements are arranged circumferentially on the surface of the device.
7. The surgically implantable device of claim 1 , wherein the biocompatible material has been mineralized.
8. The surgically implantable device of claim 1 , wherein the biocompatible material consists of a composite material comprising one or more silk fibers, twisted threads, rods, sheets or tubes in a cross-linked protein matrix.
9. The surgically implantable device of claim 8 , wherein said silk fibers, twisted threads, rods, sheets or tubes are woven, braided, embroidered or knitted together.
10. The surgically implantable device of claim 1 , wherein the device is an endoluminal device.
11. The surgically implantable device of claim 1 , wherein the device is a suture.
12. The surgically implantable device of claim 1 , wherein the device is a stent device.
13. The surgically implantable device of claim 1 , wherein the device is an anastomosis device.
14. The surgically implantable device of claim 1 , wherein the device is a sleeve to guide regenerating nerve cell processes.
15. The surgically implantable device of claim 3 , wherein said silkworm is Antheraea yamamai and said at least one silk protein is SEQ ID NO: 9.
16. The surgically implantable device of claim 3 , wherein said silkworm is Antheraea militta and said at least one silk protein is SEQ ID NO: 10.
17. The surgically implantable device of claim 1 , wherein the cross-linked protein matrix is cross-linked fibroin.
18. The surgically implantable device of claim 9 , wherein the cross-linked protein matrix is cross-linked fibroin.
19. The surgically implantable device of claim 12 , wherein the cross-linked protein matrix is cross-linked fibroin.
20. The surgically implantable device of claim 13 , wherein the cross-linked protein matrix is cross-linked fibroin.