Treatment and diagnosis of inflammatory disorders and HIV
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
1. A method of ameliorating symptoms of inflammatory autoimmune psoriasis in a mammalian subject in need thereof comprising administering to said subject a composition consisting of a pharmaceutically acceptable carrier and a therapeutically effective amount of an isolated leukotoxin set forth as SEQ ID NO: 1.
2. The method of claim 1 , wherein the autoimmune psoriasis is characterized by leukocytes expressing upregulated and activated leukocyte function antigen-1 (LFA-1) on their surface.
3. The method of claim 1 , wherein the leukotoxin is purified.
4. The method of any one of claims 1 - 3 , wherein the leukotoxin is obtained from Aggregatibacter actinomycetemcomitans.