IP Library › Granted Patent US 8,932,641
Granted Patent B2
US 8,932,641 · App. 11/990,904 · Granted Jan 13, 2015

Dried amnion and method for drying treatment of amnion

Inventors: Toshio Nikaido (Toyama, JP); Toshiko Yoshida (Toyama, JP); Motonori Okabe (Toyama, JP); Ayaka Toda (Toyama, JP); Kiyotaka Kitagawa (Toyama, JP); Masahiko Arakawa (Chikuma, JP)
Assignee: Amnos Co., Ltd.
A61L27/3641A61K35/50A01N1/02A01N1/0205A01N1/0289A61L27/3604A61L27/3683A61L2430/40C12N5/0068C12N2533/92
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Quick Facts
Patent No.
US 8,932,641
App. No.
11/990,904
Granted
Jan 13, 2015
Kind
B2
Abstract

The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.

Claims (11)

1. A dried amnion being produced by a production method comprising the steps of:

placing a raw amnion of a human or an animal in a treatment vessel; and

performing a pressure-reducing operation in the treatment vessel while an inside of the treatment vessel is heated and has a reduced inner air pressure,

then performing a pressure-recovery operation in the treatment vessel while the inside of the treatment vessel is heated and has an inner air pressure that is recovered to a level that occurred prior to performing the pressure-reducing operation, and

then repeating a sequence of the pressure-reducing operation followed by the pressure-recovery operation a plurality of times,

thereby dehydrating the raw amnion and producing the dried amnion,

wherein cellular tissues of the dried amnion are retained without being substantially broken, so that the dried amnion is storable in a sterilized dry atmosphere, and

epithelium cells, basement membranes and connective tissues which are constituents of the raw amnion are retained when the dried amnion is rehydrated in water or a buffer solution.

2. The dried amnion according to claim 1 , wherein the dried amnion is tightly sealed in a sterilized package.

3. The dried amnion according to claim 1 , wherein the dried amnion is a medical material for reconstructing a surface of an eye.

4. The dried amnion according to claim 1 , wherein the dried amnion is a medical material for treating a wound.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2014
From: NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA
To: AMNOS CO., LTD.
Reel/Frame 033296/0125 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2008
From: NIKAIDO, TOSHIO; YOSHIDA, TOSHIKO; OKABE, MOTONORI; TODA, AYAKA; KITAGAWA, KIYOTAKA; ARAKAWA, MASAHIKO
To: NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA
Reel/Frame 020606/0384 →
Priority Claims (2)
JP 2005-245964 · Aug 26, 2005 · national
JP 2006-218297 · Aug 10, 2006 · national
Continuity (1)
Related Publication 20090258082A1 · Oct 15, 2009