Dual drug delivery device
A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed.
1. A liquid delivery apparatus comprising a liquid delivery pathway, the liquid delivery pathway comprising:
a liquid reservoir comprising a deformable balloon and a pressure source selected from the group consisting of a compressive sleeve spring and an electrolytic fluid cell, the deformable balloon having an interior volume and at least one deformable interior wall in the interior volume, the at least one deformable interior wall defining a plurality of reservoir chambers in the interior volume;
a liquid metering unit fluidly connected to one of the reservoir chambers; and,
a catheter delivery tube fluidly connected to the liquid metering unit.
2. The liquid delivery apparatus of claim 1 , wherein the pressure source is a compressive sleeve spring comprising a piezoresistive material.
3. The liquid delivery apparatus of claim 1 , wherein:
the liquid metering unit comprises a throttle; and,
the liquid delivery pathway further comprises a means for measuring the volume of the liquid reservoir.
4. liquid delivery apparatus of claim 3 further comprising a liquid delivery control module, the liquid delivery control module comprising:
a microprocessor electrically connected to the throttle and the means for measuring the volume of the liquid reservoir; and,
a battery electrically connected to the microprocessor.
5. The liquid delivery apparatus of claim 4 , comprising a plurality of liquid delivery pathways, wherein the microprocessor is capable of independently controlling liquid flow through each liquid delivery pathway.
6. The liquid delivery apparatus of claim 3 further comprising a plurality of liquid delivery pathways.
7. The liquid delivery apparatus of claim 6 , comprising a liquid delivery catheter fluidly connected to the catheter delivery tube of each of the plurality of liquid delivery pathways.
8. A liquid delivery apparatus comprising:
a deformable balloon having an interior volume and at least one deformable interior wall in the interior volume, the at least one deformable interior wall defining a plurality of reservoir chambers in the interior volume; and
a plurality of liquid delivery pathways, each liquid delivery pathway comprising:
a liquid reservoir corresponding to one of the plurality of reservoir chambers;
a piezoelectrically actuated microvalve fluidly connected to the liquid reservoir; and,
a catheter delivery tube fluidly connected to the piezoelectrically actuated microvalve.
9. The liquid delivery apparatus of claim 8 , wherein the liquid reservoir further comprises a pressure source selected from the group consisting of a compressive sleeve spring, a torsion spring, and an electrolytic fluid cell.
10. The liquid delivery apparatus of claim 9 , wherein the pressure source is the compressive sleeve spring, the compressive sleeve spring comprising an alloy comprising copper, chromium, and nickel.
11. The liquid delivery apparatus of claim 8 , wherein the piezoelectrically actuated microvalve comprises:
a first plate and a second plate spaced apart and joined together to define a flow path having an inlet fluidly connected to the liquid reservoir and an outlet fluidly connected to the catheter delivery tube; and,
a piezoelectric material external to the flow path and in contact with the first plate.
12. The liquid delivery apparatus of claim 11 , wherein:
the first plate comprises a silicon-on-insulator substrate;
the second plate comprises glass; and,
the piezoelectric material comprises lead zirconium titanate.
13. The liquid delivery apparatus of claim 8 , wherein each liquid delivery pathway further comprises a means for measuring the volume of the liquid reservoir.
14. The liquid delivery apparatus of claim 13 , wherein the means for measuring the volume of the liquid reservoir comprises a pressure sensor fluidly connected to the liquid reservoir between the liquid reservoir and the piezoelectrically actuated microvalve.
15. The liquid delivery apparatus of claim 13 further comprising a liquid delivery control module, the liquid delivery control module comprising:
a microprocessor electrically connected to the piezoelectrically actuated microvalve and the means for measuring the volume of the liquid reservoir for each of the liquid delivery pathways; and,
a battery electrically connected to the microprocessor.
16. A liquid delivery apparatus comprising a liquid delivery pathway and a sensor selected from the group consisting of a flow meter fluidly connected to the liquid delivery pathway, an accelerometer, and combinations thereof;
wherein the liquid delivery pathway comprises:
a liquid reservoir comprising a deformable balloon having an interior volume and at least one deformable interior wall in the interior volume, the at least one deformable interior wall defining a plurality of reservoir chambers in the interior volume;
a liquid metering unit fluidly connected to one of the reservoir chambers; and,
a catheter delivery tube fluidly connected to the liquid metering unit.
17. The liquid delivery apparatus of claim 16 , wherein:
the liquid reservoir further comprises a pressure source selected from the group consisting of a compressive sleeve spring, a torsion spring, and an electrolytic fluid cell;
the liquid metering unit comprises a throttle; and
the liquid delivery pathway further comprises a means for measuring the volume of the liquid reservoir.
18. A liquid delivery apparatus comprising:
a liquid reservoir comprising a deformable balloon having an interior volume and at least one deformable interior wall in the interior volume, the at least one deformable interior wall defining a plurality of reservoir chambers in the interior volume;
a plurality of liquid metering units, each of which is fluidly connected to one of the reservoir chambers;
a means for measuring the volume of the liquid in the reservoir chamber; and,
a plurality of catheter delivery tubes, each of which is fluidly connected to one of the liquid metering units.
19. The liquid delivery apparatus of claim 18 , wherein
the liquid reservoir further comprises a pressure source selected from the group consisting of a compressive sleeve spring, a torsion spring, and an electrolytic fluid cell; and
each liquid metering unit comprises a throttle.
20. The liquid delivery apparatus of claim 19 , further comprising a liquid delivery control module, the liquid delivery control module comprising:
a microprocessor electrically connected to the throttle and the means for measuring the volume of the liquid in the reservoir chambers; and
a battery electrically connected to the microprocessor.