Compositions for topical treatment
A stable, self-preserving, antimicrobial, composition suitable for the treatment of a variety of dermal as well as subcutaneous conditions. The compositions include as an active ingredient a quaternary ammonium compound, preferably benzethonium chloride, potentiated and synergized with menthyl lactate cooling agent in a cationic carrier. Optionally, a phenoxyethanol preservative and chlorhexidine digluconate antibacterial agent may be used to assist in enhancing the activity. The compositions kill a broad spectrum of gram-negative and gram-positive bacteria, fungus and yeasts. The compositions are used as first aid skin treatments and as skin sanitizers to help prevent bacterial contamination of minor cuts, scrapes and burns. The compositions are particularly useful when applied to the skin after hair removal in that they additionally cool, soothe and moisturize the skin. The compositions may also serve as a base vehicle in which additional skin care ingredients may be added to provide additional functionality to the compositions.
1. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to the skin of the human a stable, antimicrobial composition consisting essentially of:
i. a cationic thickener selected from the group consisting of Polyquaternium, chitosan, hydroxyethyl cetyldimonium phosphate, and guar hydroxypropyltrimonium Chloride; and
ii. a cationic conditioning agent and emulsifier which are selected from the group consisting of behentrimonium methosulfate, cetrimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, brassicyl isoleucinate esylate, Incroquat behenyl TMS, Incroquat behenyl TMS 50, cetrimonium chloride, distearyldimonium chloride, and stearalkonium chloride; and
iii. an effective antimicrobial amount of a component selected from the group consisting of polyhexamethylene biguanide, polyaminopropyl biguanide, alexidine, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium chloride, and lysine; and
iv. an amount of a menthol-based cooling agent.
2. The method of claim 1 , wherein the amount of the menthol based cooling agent in the antimicrobial composition is between 0.1 to 7.0% by weight.
3. The method of claim 1 , wherein the effective antimicrobial amount of the antimicrobial agent is between 0.01% to 5% by weight.
4. The method of claim 1 , wherein the antimicrobial agent is selected from the group consisting of:
b. Benzethonium chloride wherein the effective antimicrobial amount is from 0.01 to 0.2% w/w;
c. Benzalkonium chloride wherein the effective antimicrobial amount is from 0.01 to 0.13% w/w; and
d. Methylbenzethonium chloride wherein the effective antimicrobial amount is 0.01 to 0.5% w/w.
5. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to the skin of the human a therapeutically effective amount of a stable, antimicrobial composition consisting essentially of:
i. a cationic thickener selected from the group consisting of Polyquaternium, chitosan, hydroxyethyl cetyldimonium phosphate, and guar hydroxypropyltrimonium Chloride; and
ii. a cationic conditioning agent and emulsifier which are selected from the group consisting of behentrimonium methosulfate, cetrimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, brassicyl isoleucinate esylate, Incroquat behenyl TMS, Incroquat behenyl TMS 50, cetrimonium chloride, distearyldimonium chloride, and stearalkonium chloride; and
iii. an effective antimicrobial amount of a component selected from the group consisting of polyhexamethylene biguanide, polyaminopropyl biguanide, alexidine, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium chloride, and lysine;
iv. an amount of a menthol-based cooling agent and;
v. a non-ionic thickener.
6. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to the skin of the human a therapeutically effective amount of a stable antimicrobial composition consisting essentially of:
i. a cationic thickener selected from the group consisting of Polyquaternium, chitosan, hydroxyethyl cetyldimonium phosphate, and guar hydroxypropyltrimonium Chloride; and
ii. a cationic conditioning agent and emulsifier which are selected from the group consisting of behentrimonium methosulfate, cetrimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, brassicyl isoleucinate esylate, Incroquat behenyl TMS, Incroquat behenyl TMS 50, cetrimonium chloride, distearyldimonium chloride, and stearalkonium chloride; and
iii. an effective antimicrobial amount of a component selected from the group consisting of polyhexamethylene biguanide, polyaminopropyl biguanide, alexidine, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium chloride, and lysine; and
iv. an amount of a menthol-based cooling agent and;
v. an amount of a non-ionic conditioning agent and a non-ionic emulsifying agent.