Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
The invention relates to the use of a chemical substance selected from the group consisting of N-′2-hydroxy-3-(1-piperidinyl)-propoxyl 1-pyridine-1-oxide-3-carboximidoyl chloride, the optically active enantiomers and the mixtures of enantiomers thereof and pharmaceutically acceptable salts of the racemic and optically active compounds in the preparation of a pharmaceutical composition for the treatment or prevention of neurodegenerative diseases.
1. A method of treating a patient with amyotrophic lateral sclerosis, said method comprising administering a therapeutically effective amount of (+)-R—N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride citrate to said patient having amyotrophic lateral sclerosis.
2. The method of claim 1 , wherein (+)-R—N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride citrate is administered as a daily dose of 0.1-400 mg/kg.
3. The method of claim 1 , wherein (+)-R—N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride citrate is administered as a daily dose of 0.1-100 mg/kg.
4. The method of claim 1 , wherein (+)-R—N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride citrate is administered as an oral daily dose of 10-300 mg.
5. The method according to claim 1 , wherein (+)-R—N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride citrate is administered at or after motoneuron degeneration onset.
6. The method according to claim 1 , wherein said amyotrophic lateral sclerosis is familial amyotrophic lateral sclerosis.