Carrier nanoparticles and related compositions, methods and systems
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
1. A polymer of formula
wherein
Functional group 1 and Functional group 2 are the same or different and independently comprise —B(OH) 2 , —OH, —COOH, or —NH 2 ,
R 3 and R 4 are independently (CH 2 CH 2 O) t , where t is from 2 to 2000,
X 1 is —NH—C(═O)—, —S—S—, —C(═O)—NH—CH 2 , —C(═O)—NH—, —O—C(═O)—, or —C(═O)—O—,
Y 1 has the formula —C m H 2m — in which m is ≧1, or is an aromatic group,
r is 1-1000,
a is 0, 1, 2, or 3, and
b is 1, 2, or 3.
2. The polymer of claim 1 wherein R 3 and R 4 are independently (CH 2 CH 2 O) t , where t is 100 to 300.
3. The polymer of claim 1 wherein X 1 is —NH—C(═O)—, —S—S—, —C(═O)—NH—CH 2 , —C(═O)—NH—, —O—C(═O)— or —C(═O)—O— and Y 1 is a phenyl group.
4. The polymer of claim 1 wherein r is 1, a is 0 and b is 1.
5. The polymer of claim 1 , wherein:
Y 1 is a phenyl group;
r is 1;
a is 0;
b is 1;
Functional group 2 comprises —OH, —COOH, or NH 2 .
6. The polymer of claim 5 , wherein
R 4 is (CH 2 CH 2 O) t , where t is 20 to 300; and
X 1 is —C(═O)—NH—.
7. The polymer of claim 1 , wherein
Y 1 is
8. The polymer of claim 7 , wherein
R 4 is (CH 2 CH 2 O) t , where t is 20 to 300;
X 1 is —C(═O)—NH—;
r is 1;
a is 0;
b is 1;
Functional group 2 comprises —OH, —COOH, or —NH 2 .