Medicament for the treatment of cancer of the pancreas
The invention relates to a suspension of red corpuscles encapsulating asparaginase as a medicament for treating pancreatic cancer. It in particular concerns a therapeutic composition or medicament intended for the treatment of pancreatic cancer, containing an effective quantity of such a suspension of red corpuscles.
1. A method for the treatment of pancreatic cancer, which comprises the administration to a human patient with pancreatic cancer of an effective dose of a suspension of red corpuscles encapsulating asparaginase.
2. The method according to claim 1 , wherein the suspension contains between 30 and 300 IU of asparaginase per ml.
3. The method according to claim 1 , wherein the suspension contains between 70 and 150 IU of asparaginase per ml.
4. The method according to claim 1 , wherein the suspension has a volume of 10 to 250 ml.
5. The method according to claim 1 , wherein one administers from 20 to 500 IU of asparaginase per kg body weight and per dose.
6. The method according to claim 1 , wherein one administers from 50 to 500 IU of asparaginase per kg body weight and per dose.
7. The method according to claim 1 , which comprises the administration to a patient in need thereof of an effective dose of a suspension of red corpuscles encapsulating asparaginase and of a chemotherapeutic agent.
8. The method according to claim 7 , wherein the chemotherapeutic agent is selected from the group consisting of gemcitabine, cisplatin, oxaliplatin and combination of 5-fluorouracil with a platinum derivative.
9. The method according to claim 7 , wherein the 5-fluorouracil is in combination with a platinum derivative selected from the group consisting of cisplatin and oxaliplatin.
10. The method according to claim 7 , wherein the chemotherapeutic agent is formulated in the suspension of red corpuscles.
11. The method according to claim 7 , wherein the chemotherapeutic agent and the suspension are administered to the patient by separate, concomitant or staggered administration.
12. The method for according to claim 1 , wherein the suspension of red corpuscles encapsulating asparaginase is administered to the patient having a pancreatic cancer, in order to increase patient survival.