Granted Patent
B2
US 8,975,409 · App. 14/347,178 · Granted Mar 10, 2015
Phenyl derivative
Inventors:
Atsushi Naganawa (Osaka, JP); Kensuke Kusumi (Osaka, JP); Kazuhiro Otsuki (Osaka, JP); Tetsuya Sekiguchi (Osaka, JP); Akito Kakuuchi (Osaka, JP); Koji Shinozaki (Osaka, JP); Hiroshi Yamamoto (Osaka, JP); Shigeyuki Nonaka (Osaka, JP)
Assignee:
ONO Pharmaceutical Co., Ltd.
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Abstract
The compound represented by the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P 2 antagonistic activity. The compound may therefore be used as a therapeutic agent for S1P 2 -mediated diseases such as diseases resulting from vascular constriction, fibrosis and respiratory diseases.
Claims (2)
1. 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid or a salt thereof.
2. 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 26, 2014
From: NAGANAWA, ATSUSHI; KUSUMI, KENSUKE; OTSUKI, KAZUHIRO; SEKIGUCHI, TETSUYA; KAKUUCHI, AKITO; SHINOZAKI, KOJI; YAMAMOTO, HIROSHI; NONAKA, SHIGEYUKI
To: ONO PHARMACEUTICAL CO., LTD.
Reel/Frame 032527/0109 →
Priority Claims (1)
JP 2011-213987
· Sep 29, 2011
· national
Continuity (1)