Angiogenesis inhibitors
Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.
1. A method of inhibiting angiogenesis in undesired tissue in a subject consisting of administering to the subject an effective amount of itraconazole.
2. The method of claim 1 , wherein the compound is administered for treatment of retinoblastoma, cystoid macular edema (CME), exudative age-related macular degeneration (AMD), diabetic retinopathy, diabetic macular edema, or ocular inflammatory disorders.
3. The method of claim 1 , wherein the undesired tissue is a tumor.
4. The method of claim 1 , wherein the undesired tissue is dermis; epidermis; endometrium; a surgical wound; or disorder or disease of the retina, gastrointestinal tract, umbilical cord, liver, kidney, reproductive system, lymphoid system, central nervous system, breast tissue, urinary tract, circulatory system, bone, muscle, or respiratory tract.
5. The method of claim 1 , wherein the undesired tissue is adipose tissue.
6. A method of inhibiting or reducing undesired angiogenesis in a subject consisting of administering to the subject an angiogenesis-inhibiting effective amount of itraconazole.
7. The method of claim 6 , wherein the compound is administered in an amount effective for treatment of retinoblastoma, cystoid macular edema (CME), exudative age-related macular degeneration (AMD), diabetic retinopathy, diabetic macular edema, or ocular inflammatory disorders.
8. The method of claim 6 , wherein the undesired angiogenesis is in a tumor.
9. The method of claim 6 , wherein the undesired angiogenesis is in a tissue selected from dermis; epidermis; endometrium; and a surgical wound; or disorder or disease of the retina, gastrointestinal tract, umbilical cord, liver, kidney, reproductive system, lymphoid system, central nervous system, breast tissue, urinary tract, circulatory system, bone, muscle, or respiratory tract.
10. The method of claim 1 or 6 , wherein the undesired tissue or angiogenesis, respectively, is associated with cancer in the subject.