Apparatus for memristor/neuron emulation and testing
View Patent ↗A method and a device are disclosed for an electronic neuron emulator for representing both passive and active electrical properties of a live neuron. The currents used to generate action potentials are derived from a pre-charged capacitor. The present invention provides for a more physiological state for testing neuroscience instruments such as the single-electrode voltage clamp and the patch clamp. The device can also include multiple pre-charged capacitors to represent ionic channels with more accurate physiologically parameters.
1. An apparatus for emulating the passive and active electrical properties of a neuron comprising:
a. a switching circuit;
b. at least two interconnected circuits including a first resistor-capacitor circuit and a second pre-charged resistor-capacitor circuit;
c. said switching circuit to alter the connectivity of the at least two interconnected circuits;
d. a processor to monitor a membrane potential in the first resistor-capacitor circuit;
e. said processor to control the firing of an action potential using the switching circuit, wherein the source of the action potential is from the charge initially stored on a capacitor in second pre-charged resistor-capacitor circuit;
and
f. an output from the first resistor-capacitor circuit using a resistor for an electrode resistance.
2. The apparatus of claim 1 , wherein an algorithm is implemented in the processor to control the firing rate of the action potential based on the membrane potential.
3. The apparatus of claim 1 , further comprising a third resistor-capacitor circuit.
4. The apparatus of claim 1 , wherein said switching circuit includes three switches.
5. The apparatus of claim 4 , wherein said action potential is generated by turning selected switches on and off.
6. The apparatus of claim 1 , wherein switching of said switching circuit comprises two stages.
7. The apparatus of claim 6 , wherein a first stage includes a configuration in which said second pre-charged resistor-capacitor circuit is disconnected from said first resistor-capacitor circuit.
8. The apparatus of claim 7 , wherein a second stage includes a configuration in which said second pre-charged resistor-capacitor circuit is connected with said first resistor-capacitor circuit.
9. The apparatus of claim 8 , wherein said firing of an action potential is accomplished by alternating between said first stage and said second stage.
10. The apparatus of claim 3 , wherein said second pre-charges resistor-capacitor circuit and said third resistor-capacitor circuit each represent different ionic channels to generate action potentials.
11. The apparatus of claim 3 , wherein said third resistor-capacitor circuit is pre-charged.