Anti-neuropilin antibodies and methods of use
The invention provides anti-NRP1 antibodies and methods of using the same.
1. An isolated antibody that binds to neuropilin-1 (NRP1), wherein the antibody comprises a VH sequence of SEQ ID NO:2 and a VL sequence of SEQ ID NO:7.
2. An isolated antibody that binds to neuropilin-1 (NRP1), wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:3, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:4, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:5, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:8, (e) HV-L2 comprising the amino acid sequence of SEQ ID NO:9, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:10.
3. The antibody of claim 2 , wherein the antibody comprises (a) a VH sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:2 and (b) a VL sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:7.
4. The antibody of claim 2 , which is an IgG1 antibody.
5. The antibody of claim 2 , which is an antibody fragment that binds neuropilin.
6. An immunoconjugate comprising the antibody of claim 2 .
7. A method of detecting the presence of NRP1 in a biological sample comprising contacting the biological sample with the antibody of claim 2 and detecting the presence of the bound antibody.
8. The method of claim 7 , wherein the presence of the bound antibody is detected by immunohistochemistry.