IP Library › Granted Patent US 8,993,617
Granted Patent B2
US 8,993,617 · App. 13/883,502 · Granted Mar 31, 2015

Ire1alpha endonuclease specific inhibitor with cytotoxic activity

Inventors: Albert C. Koong (Los Altos, CA); Ioanna Papandreou (Columbus, OH)
Assignee: The Board of Trustees of the Leland Stanford Junior University
C07D333/34A61K31/18
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Quick Facts
Patent No.
US 8,993,617
App. No.
13/883,502
Granted
Mar 31, 2015
Kind
B2
Abstract

The present invention directed to a method of treating multiple myeloma with the following compound: or a pharmaceutically acceptable salt thereof. The compound is a novel small molecule inhibitor of Ire1.

Claims (2)

1. A method of treating multiple myeloma comprising administering to a patient in need thereof an effective amount of the compound below:

or a pharmaceutically acceptable salt thereof.

Assignments (3)
CONFIRMATORY LICENSE Recorded Feb 5, 2015
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034906/0132 →
CONFIRMATORY LICENSE Recorded Nov 21, 2013
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031693/0785 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 26, 2013
From: KOONG, ALBERT C.; PAPANDREOU, IOANNA
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 030882/0990 →
Continuity (2)
Provisional Application 61412207 · Nov 10, 2010
Related Publication 20130303599A1 · Nov 14, 2013