Substituted quinoxalines and uses thereof
Disclosed herein are compounds of formula (I) and methods of inhibiting IKKβ and the NF-κB signaling and mTOR pathways.
1. A compound having a structure of formula (I)
wherein
each R 1 is independently heteroaryl, aryl, or alkyl;
L is selected from —NHC(O)NH—, —NHC(O)CH 2 —,
X is halo, alkyl, alkoxy, aryl, CO 2 alkyl, COalkyl, or haloalkyl;
R 2 is H, alkyl, alkoxy, CO 2 alkyl, COalkyl, or haloalkyl; and
R 3 is H, alkyl, or alkoxy;
or a salt thereof.
2. The compound of claim 1 , wherein each R 1 is independently selected from furanyl, thiophenyl, pyridinyl, and phenyl.
3. The compound of claim 1 , wherein at least one R 1 is methyl, ethyl, propyl, or isopropyl.
4. The compound of claim 1 , wherein L is
5. The compound of claim 1 , wherein L is
6. The compound of claim 1 , wherein X is alkoxy.
7. The compound of claim 1 , wherein X is CF 3 , CHF 2 , CH 2 F, CCl 3 , CHCl 2 , CH 2 Cl, CBr 3 , CHBr 2 , or CH 2 Br.
8. The compound of claim 1 , wherein R 2 is alkyl.
9. The compound of claim 1 , wherein R 2 is CF 3 , CHF 2 , CH 2 F, CCl 3 , CHCl 2 , CH 2 Cl, CBr 3 , CHBr 2 , or CH 2 Br.
10. A method of decreasing inhibitor of kappa B kinase β (IKKβ) activity in a cell comprising contacting the cell with the compound of claim 1 in an amount effective to decrease activity of IKKβ.
11. The method of claim 10 , wherein the compound has a structure:
or a salt thereof.
12. A method of inhibiting nuclear factor kappa Kβ(NFκB) signaling pathway in a cell comprising contacting the cell with the compound of claim 1 in an amount effective to inhibit the NFκB signaling pathway.
13. The method of claim 12 , wherein the compound has a structure:
or a salt thereof.
14. A method of inhibiting mammalian target of rapamycin (mTOR) signaling pathway in a cell comprising contacting the cell with the compound of claim 1 in an amount effective to inhibit the mTOR signaling pathway.
15. The method of claim 14 , wherein the compound has a structure:
or a salt thereof.
16. A compound selected from the group consisting of:
or a salt thereof.
17. A compound having a structure selected from:
or a salt thereof.
18. A compound having a structure selected from:
or a salt thereof.
19. A compound having a structure selected from:
or a salt thereof.
20. A compound having a structure:
or a salt thereof.