IP Library › Granted Patent US 9,005,629
Granted Patent B2
US 9,005,629 · App. 13/679,485 · Granted Apr 14, 2015

Method for treating cancer with an antibody to CD223 protein

Inventors: Drew M Pardoll (Brookeville, MD); Ching-Tai Huang (Taipei, TW); Jonathan Powell (Baltimore, MD); Charles Drake (Baltimore, MD); Dario A Vignali (Germantown, TN); Creg J Workman (Memphis, TN)
Assignees: St. Jude Children's Research Hospital Inc.; The Johns Hopkins University
A61K39/39558A01K67/0271A01K67/0276A61K39/0011C07K14/70503C07K16/2803C12N5/0636A61K39/3955C07K16/42A01K2267/0381A61K2035/122A61K2039/505A61K2039/5156A61K2039/55516C12N2501/599C12N2510/00C12N2799/027
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Quick Facts
Patent No.
US 9,005,629
App. No.
13/679,485
Granted
Apr 14, 2015
Kind
B2
Abstract

Mammals with cancer are treated with an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223. The mammal may be a human. The antibody may be a monoclonal antibody. The amount of the antibody administered may be sufficient to enhance an immune T cell response to the cancer.

Claims (5)

1. A method for treating a mammal with a cancer, comprising:

administering to the mammal an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223.

2. The method of claim 1 wherein the mammal is a human cancer patient.

3. The method of claim 1 wherein the antibody is a monoclonal antibody.

4. The method of claim 1 wherein an amount of the antibody is administered which is sufficient to enhance an immune T cell response to the cancer.

Continuity (6)
Continuation 12578887 · Oct 22, 2009
Continuation 10547371
Provisional Application 60451039 · Feb 28, 2003
Provisional Application 60482143 · Jun 24, 2003
Provisional Application 60531704 · Dec 22, 2003
Related Publication 20130095114A1 · Apr 18, 2013