IP Library Granted Patent US 9,005,682
Granted Patent B2
US 9,005,682 · App. 12/281,448 · Granted Apr 14, 2015

Synbiotic mixture

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Quick Facts
Patent No.
US 9,005,682
App. No.
12/281,448
Granted
Apr 14, 2015
Kind
B2
Abstract

This invention relates to a preparation comprising a probiotic bacterial strain and a prebiotic mixture comprising 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group comprising Ga1NAcα1,3Ga1β1,4G1c and Ga1β1,6Ga1NAcα1,3Ga1β1,4G1c, 20-95 wt % of at least one neutral oligosaccharide selected from the group comprising Ga1β1,6Ga1, Ga1β1,6Ga1β1,4G1c Ga1β1,6Ga1β1,6G1c, Ga1β1,3Ga1β1,3G1c, Ga1β1,3Ga1β1,4G1c, Ga1β 1,6Ga1β 1,6Ga1β 1,4GIc, Ga1β 1,6Ga1β 1,3Ga1β 1,4GIc Ga1β 1,3Ga1β 1,6Ga1β 1,4GIc and Ga1β1,3Ga1β1,3Ga1β1,4G1c and 2-50 wt % of at least one sialylated oligosaccharide selected from the group comprising NeuAcα2,3Ga1β1,4G1c and NeuAcα2,6Ga1β1,4G1c. The invention extends to food products comprising said preparation and to the use of the preparation in the prevention and treatment of infections.

Claims (20)

1. A preparation comprising:

a probiotic bacterial strain; and

a prebiotic mixture comprising

5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of Ga1NAcα1-3Ga1β1-4G1c, Ga1β1-6Ga1Nacα1-3Ga1β1-4G1c and combinations thereof,

20-90 wt % of at least one neutral oligosaccharide selected from the group consisting of Ga1β1-6Ga1, Ga1β1-6Ga1β1-4G1c, Ga1β1-6Ga1β1-6G1c, Ga1β1-3Ga1β1-3G1c, Ga1β1-3Ga1β1-4G1c, Ga1β1-6Ga1β1-6Ga1β1-4G1c, Ga1β1-6Ga1β1-3Ga1β1-4G1c, Ga1β1-3Ga1β1-6Ga1β1-4G1c, Ga1β1-3Ga1β1-3Ga1β1-4G1c and combinations thereof, and

5-50 wt % of at least one sialylated oligosaccharide selected from the group comprising consisting of NeuAcα2-3Ga1β1-4G1c, NeuAcα2-6Ga1β1-4G1c and combinations thereof.

2. The preparation of claim 1 , wherein the prebiotic mixture comprises 15-40 wt % of the N-acetylated oligosaccharides, 40-60 wt % of the neutral oligosaccharides and 15-30 wt % of the sialylated oligosaccharides.

3. The preparation of claim 1 , wherein the oligosaccharide mixture comprises 30 wt % of the N-acetylated oligosaccharides, 50 wt % of the neutral oligosaccharides and 20 wt % of the sialylated oligosaccharides.

4. The preparation of claim 1 , wherein the oligosaccharide mixture comprises 10-70 wt % of the N-acetylated oligosaccharides, 20-80 wt % of the neutral oligosaccharides and 10-50 wt % of the sialylated oligosaccharides.

5. The preparation of claim 1 , wherein the probiotic bacterial strain is a Lactobacillus strain.

6. The preparation of claim 5 , wherein the Lactobacillus strain is selected from the group consisting of a Lactobacillus rhamnosus , a Lactobacillus paracasei and a Lactobacillus reuteri.

7. The preparation of claim 5 , wherein the Lactobacillus strain is Lactobacillus rhamnosus CGMCC 1.3724.

8. The preparation of claim 5 , wherein the Lactobacillus train is Lactobacillus paracasei CNCM I-2116.

9. The preparation of claim 1 , wherein the probiotic bacterial strain is a Bifidobacterium strain.

10. The preparation of claim 9 , wherein the Bifidobacterium strain is selected from the group consisting of a Bifidobacterium lactis , a Bifidobacterium longum and a Bifidobacterium breve.

11. The preparation of claim 9 , wherein the Bifidobacterium strain is Bifidobacterium longum ATCC BAA-999.

12. The preparation of claim 1 , wherein the probiotic bacteria is present in an amount from 10 2 to 10 10 cfu per gram of the prebiotic mixture.

13. A food product comprising a nutritional composition and a probiotic bacterial strain and a prebiotic mixture comprising 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of Ga1NAcα1,3Ga1β1,4G1c and Ga1β1,6Ga1Nacα1,3Ga1β1,4G1c, 4G1c, 20-90 wt % of at least one neutral oligosaccharide selected from the group consisting of Ga1β1,6Ga1, Ga1β1,6Ga1β1,4G1c Ga1β1,6Ga1β1,6G1c, Ga1β1,3Ga1β1,3G1c, Ga1β1,3Ga1β1,4G1c, Ga1β1,6Ga1β1,6Ga1β1,4G1c, Ga1β1,6Ga1β1,3Ga1β1,4G1c Ga1β1,3Ga1β1,4G1c, and Ga1β1,3Ga1β1,3Ga1β1,4G1c and 5-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of NeuAcα2,3Ga1β1,4G1c and NeuAcα2,6Ga1β1,4G1c.

14. The food product as claimed in claim 13 which is an infant formula.

15. The food product as claimed in claim 13 which comprises 0.3 to 4% by weight, the probiotic bacterial strain and the prebiotic mixture, based on dry matter of the preparation.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0165 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENGLISH TRANSLATION TO SHOW THE FULL AND CORRECT NEW NAME IN SECTION 51. PREVIOUSLY RECORDED AT REEL: 049391 FRAME: 0756. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded Jun 13, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049853/0398 →
MERGER Recorded Jun 6, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049391/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 16, 2008
From: SPRENGER, NORBERT; MORGAN, FRANCOIS; BERROCAL, RAFAEL; BRAUN, MARCEL; CHERBUT, CHRISTINE; DUNCAN, PETER
To: NESTEC S.A.
Reel/Frame 021693/0122 →