Boron-containing small molecules as anti-inflammatory agents
Compounds and methods of treating anti-inflammatory conditions are disclosed.
1. A compound having a structure according to the formula:
wherein
R b is OR 4 ,
wherein R 4 is unsubstituted C 1 -C 6 alkyl, or a salt thereof.
2. The compound of claim 1 , or a salt thereof, wherein R b is OR 4 , and R 4 is a member selected from —CH 3 , —CH 2 CH 3 , —(CH 2 ) 2 CH 3 , and —CH(CH 3 ) 2 .
3. The compound of claim 1 , which is 2-(1-Hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-5-yloxy)-4-methoxy-pyrimidine-5-carbonitrile.
4. A pharmaceutical formulation comprising:
(a) the compound of claim 1 , or a pharmaceutically acceptable salt thereof;
(b) a pharmaceutically acceptable excipient.
5. The formulation of claim 4 , wherein the formulation is in a unit dosage form.
6. The formulation of claim 4 , wherein the formulation is for oral or topical use.