IP Library › Granted Patent US 9,017,981
Granted Patent B2
US 9,017,981 · App. 13/201,969 · Granted Apr 28, 2015

Identification of extracellular form of PTEN that can be used to treat tumors

Inventor: Ramon Parsons (Manhasset, NY)
Assignee: The Trustees of Columbia University in the City of New York
C12N9/16A61K38/00
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Quick Facts
Patent No.
US 9,017,981
App. No.
13/201,969
Granted
Apr 28, 2015
Kind
B2
Abstract

An isolated human phosphatase and tensin homolog long polypeptide (PTEN-long) comprising SEQ ID NO:1, fragments and analogs thereof, nucleic acids encoding such and compositions comprising such are provided. Methods to inhibit angiogenesis in a solid tumor, treat a solid tumor, and inhibit growth of a solid tumor using PTEN-long, fragments and analogs thereof, are provided.

Claims (1)

1. A method for treating a solid tumor in a subject comprising administering to the subject an amount of an isolated polypeptide effective to treat the solid tumor in the subject, wherein the sequence of the polypeptide is identical to the sequence set forth in in SEQ ID NO: 1.

Assignments (2)
CONFIRMATORY LICENSE Recorded Nov 29, 2011
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 027290/0421 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 2, 2011
From: PARSONS, RAMON
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 027160/0462 →
Continuity (2)
Provisional Application 61207974 · Feb 17, 2009
Related Publication 20120039861A1 · Feb 16, 2012