Granted Patent
B2
US 9,018,003 · App. 11/914,167 · Granted Apr 28, 2015
Modulators of alpha-synuclein toxicity
Inventors:
Susan L. Lindquist (Chestnut Hill, MA); Aaron D. Gitler (Philadelphia, PA); Anil Cashikar (Martinez, GA)
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Abstract
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Claims (3)
1. A cell comprising a first expression vector encoding alpha synuclein and a second expression vector encoding SIT4.
2. The cell of claim 1 , wherein the cell is a yeast cell.
3. The cell of claim 1 , wherein the cell is a mammalian cell.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Mar 30, 2009
From: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022466/0619 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 20, 2008
From: LINDQUIST, SUSAN L.; GITLER, AARON D.; CASHIKAR, ANIL
To: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
Reel/Frame 021707/0704 →
Continuity (3)
Provisional Application
60681126
· May 13, 2005
Provisional Application
60756853
· Jan 6, 2006