IP Library Granted Patent US 9,028,870
Granted Patent B2
US 9,028,870 · App. 12/979,278 · Granted May 12, 2015

Hydrogel-driven drug dosage form

Inventors: Leah E. Appel (Bend, OR); Ronald A. Beyerinck (Bend, OR); Mark B. Chidlaw (Bend, OR); William J. Curatolo (Niantic, CT); Dwayne T. Friesen (Bend, OR); Kelly L. Smith (Bend, OR); Avinash G. Thombre (East Lyme, CT)
Assignee: Bend Research, Inc.
A61K9/0004
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Quick Facts
Patent No.
US 9,028,870
App. No.
12/979,278
Granted
May 12, 2015
Kind
B2
Abstract

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.

Claims (5)

1. A controlled release drug dosage form comprising a core and a coating around said core, said coating consisting of a mixture of cellulose acetate and polyethylene glycol, wherein said core comprises a drug-containing composition and a water-swellable composition, each occupying separate regions within said core and wherein

(a) said drug-containing composition comprises a drug, the drug-entraining agent polyethylene oxide, and the fluidizing agent selected from the group consisting of sugars and organic acids; and

(b) said coating is water-permeable, water-insoluble, has at least one delivery port therethrough, and a durability of at least 1 Kp/cm 2 ; and wherein said coating is formed from a substantially homogeneous solution comprising a solvent, said cellulose acetate, said polyethylene glycol, and at least 4 wt % of the non-solvent water but not greater than a weight percent such that a cloud point of the solution is reached when the solution is at room temperature, wherein a weight ratio of cellulose acetate to polyethylene glycol of from 8:2 to 6.5:3.5.

2. The dosage form of claim 1 wherein said coating is formed from a solution containing at least 15 wt % water but not greater than a weight percent such that a cloud point of the solution is reached.

3. The dosage form of claim 1 , wherein said water swellable composition comprises polyethylene oxide, microcrystalline cellulose, and an osmagent selected from magnesium sulfate, magnesium chloride, calcium chloride, sodium chloride, lithium chloride, potassium sulfate, sodium carbonate, sodium sulfite, lithium sulfate, potassium chloride, sodium sulfate, d-mannitol, urea, sorbitol, inositol, raffinose, sucrose, glucose, fructose, lactose, and mixtures thereof.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2013
From: APPEL, LEAH E.; BEYERINCK, RONALD A.; CHIDLAW, MARK B.; FRIESEN, DWAYNE T.; SMITH, KELLY L.
To: BEND RESEARCH, INC.
Reel/Frame 031235/0424 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2013
From: CURATOLO, WILLIAM J.; THOMBRE, AVINASH G.
To: PFIZER INC.; PFIZER PRODUCTS INC.
Reel/Frame 031235/0432 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2013
From: BEND RESEARCH, INC.
To: PFIZER INC.; PFIZER PRODUCTS INC.
Reel/Frame 031235/0436 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2011
From: PFIZER INC.; PFIZER PRODUCTS INC.
To: BEND RESEARCH, INC.
Reel/Frame 025989/0621 →
Continuity (4)
Division 11610603 · Dec 14, 2006
Continuation 09745095 · Dec 20, 2000
Provisional Application 60171968 · Dec 23, 1999
Related Publication 20110182947A1 · Jul 28, 2011