IP Library Granted Patent US 9,034,388
Granted Patent B2
US 9,034,388 · App. 12/057,775 · Granted May 19, 2015

Bioeffective krill oil compositions

Inventors: Inge Bruheim (Volda, NO); Mikko Griinari (Espoo, FI); Snorre Tilseth (Bergen, NO); Sebastiano Banni (Cagliari, IT); Jeffrey Stuart Cohn (Camperdown, AU); Daniele Mancinelli (Orsta, NO)
Assignee: AKER BIOMARINE ANTARTIC AS
A61K35/612A61K9/4858A61K31/122A61K31/23A61K31/683A61K31/685A61K45/06C11B3/006A61K31/202
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Quick Facts
Patent No.
US 9,034,388
App. No.
12/057,775
Granted
May 19, 2015
Kind
B2
Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

Claims (7)

1. A method of producing krill oil containing phospholipids comprising:

a) cooking and drying krill to provide cooked and dried krill meal;

b) contacting said cooked and dried krill meal with a polar solvent to extract a krill oil containing phospholipids from said cooked and dried krill meal, wherein said krill oil containing phospholipids comprises from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-ether phospholipids so that the amount of total phospholipids in the composition is from about 30% to 60% w/w; and from about 20% to 50% w/w triglycerides; and

c) providing a dilapidated krill meal following said extraction comprising greater than 65% protein and less than 50 g/kg total fat.

2. The method of claim 1 , wherein said cooked and dried krill meal is stored prior to said contacting step.

3. The method of claim 1 , wherein said contacting step further comprises extraction by supercritical fluid extraction.

4. The method of claim 3 , wherein said supercritical fluid extraction is a two step process comprising a first extraction step with carbon dioxide and from 1 to 10% of a co-solvent and a second extraction step with carbon dioxide and from 10-30% of a co-solvent, wherein said co-solvent in said first and second extraction steps is a C 1 -C 3 monohydric alcohol.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2015
From: AKER BIOMARINE AS
To: AKER BIOMARINE ANTARCTIC AS
Reel/Frame 034734/0841 →
MERGER Recorded Feb 13, 2013
From: AKER BIOMARINE ASA
To: AKER BIOMARINE AS
Reel/Frame 029802/0828 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF THE <RECEIVING PARTY> FROM "AKAR BIOMARINE ASA" TO "AKER BIOMARINE ASA" PREVIOUSLY RECORDED ON REEL 021250 FRAME 0557. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 12, 2009
From: BRUHEIM, IGNE; TILSETH, SNORRE; COHN, JEFFREY; GRIINARI, MIKKO; BIANNI, SEBASTIANO; MANCINELLI, DANIELE
To: AKER BIOMARINE ASA
Reel/Frame 023089/0864 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2008
From: BRUHEIM, INGE; TILSETH, SNORRE; COHN, JEFFREY; BANNI, SEBASTIANO; MANCINELLI, DANIELE; GRIINARI, MIKKO
To: AKAR BIOMARINE ASA
Reel/Frame 021250/0557 →
Continuity (5)
Provisional Application 60920483 · Mar 28, 2007
Provisional Application 60975058 · Sep 25, 2007
Provisional Application 60983446 · Oct 29, 2007
Provisional Application 61024072 · Jan 28, 2008
Related Publication 20080274203A1 · Nov 6, 2008