Anti-microbial composition and method for making and using same
The present invention generally relates to anti-microbial formulations and methods of their use and production. The formulations of the present invention are effective as broad spectrum anti-bacterial agents with efficacy against both Gram-negative and Gram-positive bacteria, as anti-viral agents with efficacy against both enveloped and non-enveloped viruses, and as anti-fungal agents with efficacy against both vegetative and spore forms of microorganisms and against biofilms. The present invention includes anti-microbial compositions that have at least one surfactant, at least one acid, at least one peroxide (preferably hydrogen peroxide), peracetic acid, and water. The anti-microbial Formulations of the present invention may additionally contain an organic salt. The organic salt may be a salt of the same acid that is used in the Formulation or a salt of a different acid. Methods for production and use of the inventive compositions are disclosed.
1. An anti-microbial composition comprising:
a given amount of a given surfactant selected from the group consisting of 0.6%, 1%-4%, 6% and 10% of a poloxamer L-31, 0.6%, 3%, 4% and 6% of a poloxamer L-43, 3% of a poloxamer L-61, 2%, 3% and 4% of a poloxamer L-121, 0.1% of a poloxamer F-38, 6% of a poloxamer F-87, 2% of a poloxamer F-127 and 6% octylphenol ethoxylate 7.5, the poloxamer L-31 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 1100, an approximate molecular weight of the propylene oxide block of 950, and approximately 10% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer, the poloxamer L-43 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 2500, an approximate molecular weight of the propylene oxide block of 1750, and approximately 20% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer, the poloxamer L-61 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 2000, an approximate molecular weight of the propylene oxide block of 1750, and approximately 10% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer, the poloxamer L-121 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 4400, an approximate molecular weight of the propylene oxide block of 4000, and approximately 10% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer, the poloxamer F-38 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 5000, an approximate molecular weight of the propylene oxide block of 950, and approximately 80% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer, the poloxamer F-87 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 7700, an approximate molecular weight of the propylene oxide block of 2250, and approximately 70% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer, the poloxamer F-127 including an approximate molecular weight of propylene oxide/ethylene oxide block copolymer of 12500, an approximate molecular weight of the propylene oxide block of 4000, and approximately 70% ethylene oxide content in the propylene oxide/ethylene oxide block copolymer;
citric acid;
hydrogen peroxide; and
peracetic acid;
wherein the citric acid:hydrogen peroxide; peracetic acid ratio is equivalent to 0.7-3 citric acid:0.7-3 hydrogen peroxide:1-1.4 peracetic acid by weight; and
the composition is not corrosive to ferrous metal after at least 2 hours of contact with the metal.
2. The anti-microbial composition of claim 1 further comprising water.
3. The anti-microbial composition of claim 1 further comprising a lower alkyl alcohol wherein the alkyl group contains from 1 to 8 carbon atoms.
4. The anti-microbial composition of claim 3 wherein the alcohol is selected from the group consisting of methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, t-butanol, butyl cellusolve and combinations thereof.
5. The anti-microbial composition of claim 2 further comprising:
an organic salt.
6. The anti-microbial composition of claim 5 wherein the salt is selected from the group consisting of sodium citrate, potassium phthalate, sodium benzoate and combinations thereof.
7. The anti-microbial composition of claim 5 wherein the organic salt is a salt of citric acid.
8. The anti-microbial composition of claim 1 wherein the surfactant is present in a concentration of about 1% to 6% by weight, the citric acid is present in a concentration of about 0.01% to 20% by weight, the hydrogen peroxide is present in a concentration of about 0.1% to 20% by weight; and the peracetic acid is present in a concentration of about 0.05% to 30% by weight.
9. The anti-microbial composition of claim 1 wherein the surfactant is present in a concentration of about 3% to 4% by weight; the citric acid is present in a concentration of about 0.02% to 15% by weight, the hydrogen peroxide is present in a concentration of about 0.4% to 15% by weight, and the peracetic acid is present in a concentration of about 0.2% to 20% by weight.
10. The anti-microbial composition of claim 9 wherein the surfactant is present in a concentration of about 0.10% to 10% by weight; the citric acid is present in a concentration of about 0.6% to 10% by weight, the hydrogen peroxide is present in a concentration of about 0.7% to 10% by weight, and the peracetic acid is present in a concentration of about 0.3% to 14% by weight.
11. The anti-microbial composition of claim 1 which exhibits a zone of inhibition having a diameter of 25 mm to 70 mm; a Plate Cidality against each of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa , and Candida albicans at aqueous dilutions up to 1:2000; and is CPE positive.
12. The anti-microbial composition of claim 1 further
comprising an additional non-cationic antimicrobial agent which is different from the peroxy compound or peracetic acid.
13. The anti-microbial composition of claim 12 wherein the additional non-cationic antimicrobial agent is selected from the group consisting of phenolics, halogenated phenolics, halogenated diphenyl ethers, and halogenated carbonilides, peroxy oxidizing agents, and combinations thereof.
14. The anti-microbial composition of claim 1 further comprising: a wetting agent present an amount of from about 0.1 to 3% by weight.
15. The anti-microbial composition of claim 1 which exhibits an anti-microbial effect on microbes selected from the group consisting of bacillus anthracis and clostridium difficile.
16. The anti-microbial composition of claim 1 in the form of soap.
17. The antimicrobial composition of claim 1 which comprises about 0.1% poloxamer, about 1.8% citric acid, about 1.8% hydrogen peroxide, and about 0.6% peracetic acid, with the balance being water containing about 100 ppm sodium pyrophosphate.
18. The antimicrobial composition of claim 1 which comprises about 0.1% poloxamer, about 1.8% citric acid, about 1.8% hydrogen peroxide, about 0.6% peracetic acid, and about 3.0% t-butyl hydroperoxide, with the balance being water containing about 100 ppm sodium pyrophosphate.
19. The antimicrobial composition of claim 1 which comprises about 0.1% poloxamer, about 3.0% citric acid, about 3.0% hydrogen peroxide, about and 3.0% peracetic acid, with the balance being water containing about 100 ppm sodium pyrophosphate.
20. The antimicrobial composition of claim 1 which comprises about 0.1% poloxamer, about 1.8% sodium citrate, about 1.8% hydrogen peroxide, 0.6% peracetic acid, about and 4.0% ethanol, with the balance being water containing about 100 ppm sodium pyrophosphate.