Bifunctional/polyfunctional dopamine D2/D3 agonist as neuroprotective agents for treatment of neurodegenerative diseases
A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula M x L y where M is a metal and L is an amidrazone-derived ligand or an amidate-derived ligand. A process of forming a thin film using the precursors is also provided.
1. A compound having formula I for treating a neurodegenerative disease:
or a pharmaceutically acceptable salt thereof;
wherein:
R 1 is C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, or C 6-10 aryl;
is
R 2 groups are C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl; C 6-10 aryl, —NR 3 q where R 3 individually are H, C 1-8 alkyl, C 2-8 alkenyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, C 6-10 aryl and q is 2;
o is 0, 1, 2, 3, or 4;
A is quinolinyl or an optionally substituted quinolinyl, the optionally substituted quinolinyl being substituted by a component selected from the group consisting of —OH, C 1-4 alkyl, C 2-4 alkenyl, C 5-7 cycloalkyl, C 5-7 cycloalkenyl, halo, C 1-4 aldehyde, and —NR 4 q where R 4 is H, C 1-8 alkyl, C 2-8 alkenyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, or C 6-10 aryl; and q is 2;
p is an integer from 1 to 6; and
Z m is absent, —CH 2 — or —CO—.
2. The compound of claim 1 having formula IIa or IIb:
wherein R 6 and R 7 are Cl, F, OH, H, C 1-8 alkyl, C 2-8 alkenyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, or C 6-10 aryl.
3. The compound of claim 1 having formula IIIa or formula IIIb:
wherein R 6 and R 7 are Cl, F, OH, H, C 1-8 alkyl, C 2-8 alkenyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, or C 6-10 aryl.
4. A compound selected from the group consisting of:
and pharmaceutically acceptable salt thereof, wherein R is hydrogen or C 1-4 alkyl.
5. The compound of claim 4 wherein R is hydrogen.
6. A compound selected from the group consisting:
and pharmaceutically acceptable salts thereof, wherein R is hydrogen or C 1-4 alkyl, and n is 0, 1, 2 or 3.
7. The compound of claim 6 wherein R is hydrogen.
8. The compound of claim 1 wherein A is substituted by a component selected from the group consisting of C 1-4 alkyl, C 2-4 alkenyl, C 5-7 cycloalkyl, C 5-7 cycloalkenyl, halo, C 1-4 aldehyde, and —NR 4 q where R 4 is H, C 1-8 alkyl, C 2-8 alkenyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, or C 6-10 aryl; and q is 2.
9. The compound of claim 1 wherein A is substituted by a component selected from the group consisting of C 1-4 alkyl, C 2-4 alkenyl, C 5-7 cycloalkyl, C 5-7 cycloalkenyl, and halo.
10. The compound of claim 1 wherein:
11. The compound of claim 1 having a formula selected from the group consisting of:
wherein R is hydrogen or C 1-4 alkyl.