Synthetic analogues of neural regeneration peptides
Embodiments of this invention include synthetic compounds (NRP analogues) of peptides termed neural regeneration peptides (NRPs). NRP analogues are made by substituting amino acids in the native peptide sequence, modifying amino acids chemically, by replacing amino acids with synthetic moieties, by stabilizaing β-turns, acetylation of terminal glycine residues or by cyclization. NRP analogues can be used to treat a variety of conditions involving degeneration of neural cells, and includes treating disorders of the nervous system, including peripheral neuropathy, multiple sclerosis, diabetic peripheral neuropathy, neurotoxin-induced neurodegeneration, and amyotrophic lateral sclerosis.
1. A method for the treatment of peripheral neuropathy, multiple sclerosis and amyotrophic lateral sclerosis in an animal, comprising administering to said animal a pharmaceutically effective amount of a neural regeneration peptide (NRP) compound comprising an amino acid sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6, or a pharmaceutical composition comprising a NRP compound comprising an amino acid sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6 and a pharmaceutically acceptable excipient.
2. The method of claim 1 , wherein said NRP compound consists of the sequence SEQ ID NO:5.
3. The method of claim 1 , wherein said NRP compound consists of the sequence SEQ ID NO:6.