Antibacterial compounds and methods of using same
Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.
1. A compound having the formula
or a pharmaceutically acceptable salt thereof, wherein
R=H or CF 3 .
2. The compound of claim 1 wherein R is H.
3. The compound of claim 1 wherein R is CF 3 .
4. A pharmaceutical composition comprising a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
5. A method for inhibiting growth of gram positive bacteria comprising contacting gram positive bacteria with a compound of claim 1 , thereby inhibiting the growth of the bacteria.
6. The method of claim 5 wherein the contacting is performed in vivo in a human or animal.
7. The method of claim 6 wherein the gram positive bacteria is of the genus Enterococcus or Staphylococcus.
8. A compound of Formula (X):
wherein
R 2 and R 5 are each independently C or N; and
R 1 , R 3 and R 4 are each independently N or CH, provided that at least one of R 1 -R 5 is C or CH;
or a pharmaceutically acceptable salt thereof.
9. The compound:
or a salt thereof.
10. A pharmaceutical composition comprising the compound:
or a salt thereof; in combination with a pharmaceutically acceptable carrier.