IP Library › Granted Patent US 9,045,475
Granted Patent B2
US 9,045,475 · App. 13/830,926 · Granted Jun 2, 2015

Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Inventors: Steven W. Elmore (Northbrook, IL); Andrew J. Souers (Evanston, IL); Zhi-Fu Tao (Gurnee, IL)
Assignees: ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA INSTITUTE OF MEDICAL RESEARCH
C07D471/04C07D401/14C07D519/00C07D209/82C07D403/12A61K31/496
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Quick Facts
Patent No.
US 9,045,475
App. No.
13/830,926
Granted
Jun 2, 2015
Kind
B2
Abstract

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Claims (2)

1. 4-(4-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising an excipient and a therapeutically effective amount of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof.

Continuity (3)
Continuation 12787682 · May 26, 2010
Provisional Application 61181203 · May 26, 2009
Related Publication 20130267534A1 · Oct 10, 2013