Prostatitis-associated antigens and methods of use thereof
The present disclosure provides prostatitis-associated antigens, and compositions comprising the antigens. The present disclosure provides diagnostic methods, generally involving assaying the level of an immune response specific for a prostatitis-associated antigen in an individual. Kits suitable for use in performing such diagnostic assays are also provided. The present disclosure further provides methods of treating prostatitis, methods of treating prostate cancer, and methods of treating benign prostatic hyperplasia.
1. A method of diagnosing an individual as having prostatitis, the method comprising:
assaying the level of T cells specific for a human semenogelin polypeptide in a biological sample obtained from the individual;
identifying the individual as having prostatitis when the level of T cells specific for the human semenogelin polypeptide is greater than a normal control level; and
outputting a report indicating the level of T cells specific for the human semenogelin polypeptide.
2. The method of claim 1 , wherein said biological sample is serum, blood, plasma, or seminal fluid.
3. The method of claim 1 , wherein said individual is a human male.
4. The method of claim 1 , wherein said individual has a higher than normal level of prostate-specific antigen.
5. The method of claim 1 , further comprising assaying the level of prostate specific antigen (PSA) in the biological sample, wherein the level of PSA provides for diagnosis of prostate cancer.