Compositions comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent

1. A cosmetic or pharmaceutical composition for reducing human skin irritation comprising:

a) 0.1-4.5 wt. % of trans-4-tert-butyl cyclohexanol or a cosmetically or pharmaceutically acceptable salt thereof, based on the total weight of the composition; and

b) one or more cosmetically or pharmaceutically acceptable carriers;

wherein if the composition comprises cis-4-tert-butyl cyclohexanol, the weight ratio of the trans-4-tert-butyl cyclohexanol to the cis-4-tert-butyl cyclohexanol is at least 90:10.

2. The composition according to claim 1 , wherein the one or more cosmetically acceptable carriers b) are selected from the group consisting of

(i) alkane diols having 3 to 10 carbon atoms,

(ii-1) esters having 6 to 36 carbon atoms,

(ii-2) branched and unbranched alkyl or alkenyl alcohols, and

(ii-3) branched and unbranched hydrocarbons and waxes, cyclic or linear silicone oils and dialkyl ethers having 6 to 24 carbon atoms.

3. The composition according to claim 1 , further comprising at least one fragrance.

4. The composition according to claim 1 , further comprising at least one additional active ingredient that provides a benefit to the skin.

5. The composition according to claim 4 , wherein the at least one additional active ingredient is selected from the group consisting of:

extracts or fractions from camomile, Aloe vera, oats, calendula, arnica, honeysuckle, rosemary, witch hazel, ginger or Echinacea;

alpha-bisabolol, gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols, natural avenanthramides, non-natural avenanthramides, boswellic acid, phytosterols, glycyrrhizin, or licochalcone A; and

urea, hyaluronic acid, allantoin, panthenol, lanolin, alpha-hydroxy acids, or vitamin E or derivatives.

6. The composition according to claim 1 , wherein the composition is selected from the group consisting of a cosmetic product for treatment, protection, care and cleansing of the skin and/or hair and a make-up product.

7. A concentrated composition comprising

5 to 55 wt. % trans-4-tert-butyl cyclohexanol; and

at least one diol having 3 to 10 carbon atoms;

wherein if the composition comprises cis-4-tert-butyl cyclohexanol, the weight ratio of the trans-4-tert-butyl cyclohexanol to the cis-4-tert-butyl cyclohexanol is at least 90:10.

8. A cosmetic formulation or medicament comprising the composition according to claim 7 .

9. The cosmetic composition according to claim 1 , wherein the one or more cosmetically acceptable carriers are not water or ethanol.

10. The composition according to claim 2 , wherein the one or more cosmetically acceptable carriers b) are selected from the group consisting of

(i) 1,2-propylene glycol, 2-methylpropane-1,3-diol, 1,2-butylene glycol, 1,3-butanediol, 1,2-pentanediol, 1,3-pentanediol, 1,5-pentanediol, 2,4-pentanediol, 2-methyl-pentane-2,4-diol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, or dipropylene glycol;

(ii-1) diethyl phthalate, diethylhexyl 2,6-naphthalate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate, 2-ethylhexyl isononanoate, 2-ethylhexyl 3,5,5-trimethylhexanoate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, cetearyl ethylhexanoate, stearyl heptanoate, stearyl caprylate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, 2-ethylhexyl isostearate, isotridecyl isononanoate, 2-ethylhexyl cocoate, C 12-15 -alkyl benzoates, cetyl palmitate, triethyl citrate, triacetin, benzyl benzoate, benzyl acetate, or vegetable oils and triglycerides;

(ii-2) decanol, decenol, octanol, octenol, dodecanol, dodecenol, octadienol, decadienol, dodecadienol, oleyl alcohol, ricinoleyl alcohol, erucyl alcohol, stearyl alcohol, isostearyl alcohol, cetyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, linoleyl alcohol, linolenyl alcohol, hexyldecanol, or octyldodecanol and cetearyl alcohol and behenyl alcohol; and

(ii-3) jojoba oil, isoeicosane, dicaprylyl ether, mineral oil, petrolatum, squalane, squalene, cyclomethicone, decamethylcyclopentasiloxane, undecamethylcyclotrisiloxane, polydimethylsiloxane or poly(methyl-phenyl siloxane.

11. The composition according to claim 3 , further comprising at least one fragrance having a C log P value of at least 3.

12. The composition according to claim 3 , further comprising at least one fragrance selected from the group consisting of: alpha-amyl cinnamic aldehyde, alpha-hexyl cinnamic aldehyde, 2-phenoxyethylisobutyrate, methyl dihydrojasmonate, 4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran, benzylsalicylate, 2-methyl-3-(4-tert-butyl-phenyl)propanal, 4,7-methano-3a,4,5,6,7,7a-hexahydro-5-indenyl acetate and/or 4,7-methano-3a,4,5,6,7,7a-hexahydro-6-indenyl acetate, styrallyl acetate, octahydro-2,3,8,8-tetramethyl-2-acetonaphthone and/or 2-acetyl-1,2,3,4,6,7,8-octahydro-2,3,8,8-tetramethylnaphthaline, hexylsalicylate, 4-tert.-butylcyclohexyl acetate, 2-tert.-butylcyclohexyl acetate, alpha-ionone, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene carboxaldehyde, (E)- and/or (Z)-3-methylcyclopentadec-5-enone, 15-pentadec-11-enolide and/or 15-pentadec-12-enolide, 15-cyclopentadecanolide, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)ethanone, ethylene brassylate, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, alpha-Santalol, 2,2-dimethyl-3-(3-methylphenyl)-propanol (Majantol), allyl heptanoate, 4-methylacetophenone, (4aR,5R,7aS,9R)-octahydro-2,2,5,8,8,9a-hexamethyl-4H-4a,9-methanoazuleno(5,6-d)-1,3-dioxol), 1-(2,2,6-trimethylcyclohexyl)hexan-3-ol, benzylacetone, methyl cinnamate, and 3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan.

13. The composition according to claim 4 , wherein the additional active ingredient that provides a benefit to the skin is selected from the group consisting of anti-inflammatory agents, physiological cooling agents, compounds that alleviate itching and compounds that alleviate reddening, wherein the active is suitable for cosmetic and/or dermatological applications.

14. The concentrated composition according to claim 7 , comprising 7.5 wt. % or more of an alkane diol selected from the group consisting of 1,2-propylene glycol, 2-methylpropane-1,3-diol, 1,2-butylene glycol, 1,3-butanediol, 1,2-pentanediol, 1,3-pentanediol, 1,5-pentanediol, 2,4-pentanediol, 2-methyl-pentane-2,4-diol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, and dipropylene glycol.

15. The composition according to claim 1 , wherein if the composition comprises cis-4-tert-butyl cyclohexanol, the weight ratio of the trans-4-tert-butyl cyclohexanol to the cis-4-tert-butyl cyclohexanol is at least 95:5.

16. A cosmetic or pharmaceutical composition for reducing human skin irritation comprising:

a) 0.1-4.5 wt. % of trans-4-tert-butyl cyclohexanol or a cosmetically or pharmaceutically acceptable salt thereof, based on the total weight of the composition,

wherein if the composition comprises cis-4-tert-butyl cyclohexanol, the weight ratio of the trans-4-tert-butyl cyclohexanol to the cis-4-tert-butyl cyclohexanol is at least 95:5;

b) one or more cosmetically or pharmaceutically acceptable carriers selected from the group consisting of:

(i) an alkane diol having 3 to 10 carbon atoms,

(ii-1) an ester having 6 to 36 carbon atoms,

(ii-2) a branched or unbranched alkyl or alkenyl alcohol, and

(ii-3) a branched or unbranched hydrocarbon, a wax, a cyclic or linear silicone oil, or an ether having 6 to 24 carbon atoms; and

c) at least one fragrance having a C log P value of at least 3.

17. The composition according to claim 16 , further comprising:

(d) an additional active ingredient suitable for cosmetic application to the skin selected from the group consisting of an anti-inflammatory agent, a physiological cooling agent, a compound that alleviates itching, and a compound that alleviates reddening.

18. The composition according to claim 16 comprising (i) an alkane diol having 3 to 10 carbon atoms selected from the group consisting of 1,2-propylene glycol, 2-methylpropane-1,3-diol, 1,2-butylene glycol, 1,3-butanediol, 1,2-pentanediol, 1,3-pentanediol, 1,5-pentanediol, 2,4-pentanediol, 2-methyl-pentane-2,4-diol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, and dipropylene glycol.

19. A method for reducing human skin irritation comprising applying to the skin of a human an effective amount of a cosmetic composition according to claim 1 .