N-acyldipeptide derivatives and their uses
N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with a tumor, cancer, immune, nervous, vascular, musculoskeletal or cutaneous system, or other tissue or system in a subject.
1. A method of treating eczema, itch, pruritus, psoriasis, or dermatitis in a subject in need thereof, comprising topically administering to the skin of the subject a composition comprising a therapeutically effective amount of a dipeptide derivative having the following generic Formula (I):
R 1 -AAB-AAC-R 2 Formula (I)
or an isomer or salt thereof, and optionally a pharmaceutically or cosmetically acceptable carrier, wherein R 1 is an acyl radical having up to 9 carbon atoms; AAB is tyrosine and AAC is tyrosine, or AAB is valine and AAC is alanine; R 2 is OR 3 , NHR 4 or NHNHR 5 ; R 3 is H, an alkyl, aralkyl or aryl radical having up to 19 carbon atoms; and R 4 or R 5 is independently H, OH, an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms.
2. The method of claim 1 , wherein the dipeptide derivative is selected from the group consisting of N—Ac-Tyr-Tyr-NH 2 , N—Ac-Tyr-Tyr-OH, N—Ac-Tyr-Tyr-OEt, N—Ac-Tyr-Tyr-NHNH 2 , N—Ac-Tyr-Tyr-NHNHAc, N—Ac-Tyr-Tyr-NHOH, N—Pr-Tyr-Tyr-NH 2 , N—Pr-Tyr-Tyr-OH, N—Pr-Tyr-Tyr-OEt, N—Pr-Tyr-Tyr-NHNH 2 , and N—Pr-Tyr-Tyr-NHNHPr.
3. The method of claim 1 , wherein the dipeptide derivative is selected from the group consisting of N—Ac-Val-Ala-NH 2 , N—Ac-Val-Ala-OH, N—Ac-Val-Ala-NHOH, N—Pr-Val-Ala-NH 2 , and N—Pr-Val-Ala-OH.