Chimeric fibronectin matrix mimetics and uses therof
The present invention is directed to recombinant fibronectin peptide mimetics and wound healing compositions containing the same. Other aspects of the present invention include wound healing dressings that comprise the wound healing composition of the present invention and a wound dressing material and methods of treating wounds using these compositions.
1. A recombinant fibronectin peptide mimetic comprising:
(i) at least a portion of the type III heparin-binding domain FNIII1H of fibronectin, wherein said portion comprises a heparin binding sequence and
at least a portion of the type III integrin-binding domain FNIII8-10 of fibronectin, wherein said portion comprises an integrin binding sequence and wherein said portion does not contain FNIII9 in its entirety, wherein the at least a portion of the type III integrin binding domain comprises an amino acid sequence corresponding to amino acids 1266-1356 of SEQ ID NO:1 linked to amino acids 1447-1536 of SEQ ID NO: 1.
2. A recombinant fibronectin peptide mimetic comprising:
(i) at least a portion of the type III heparin-binding domain FNIII1H of fibronectin, wherein said portion comprises a heparin binding sequence and
(ii) at least a portion of the type III integrin-binding domain FNIII8-10 of fibronectin, wherein said portion comprises an integrin binding sequence and wherein said portion does not contain FNIII9 in its entirety, wherein the peptide comprises-an amino acid sequence of SEQ ID NO: 3.