Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
1. An antimicrobial ophthalmic composition for direct application onto an eye of a living being, the composition consisting of from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound, wherein the composition does not contain chlorine dioxide prior to application to the eye of the living being, and wherein the composition is at a pH range between about 6.0 and 8.8.
2. The antimicrobial ophthalmic composition of claim 1 wherein the chlorite compound is a metal chlorite.
3. The antimicrobial ophthalmic composition of claim 2 wherein the metal is sodium.
4. The antimicrobial ophthalmic composition of claim 2 wherein the metal is selected from the group consisting of potassium, calcium, and magnesium.
5. The antimicrobial ophthalmic composition of claim 1 wherein the peroxy compound is hydrogen peroxide.
6. The antimicrobial ophthalmic composition of claim 1 additionally consisting of a lubricant chosen from the group consisting of non-ionic polymeric lubricants, anionic polymeric lubricants, and combinations thereof.
7. The antimicrobial ophthalmic composition of claim 6 additionally consisting of a block polymer based surfactant.
8. The antimicrobial ophthalmic composition of claim 6 wherein the ophthalmic composition additionally consisting of:
lubricant
0.05 wt. % to 0.3 wt. %;
boric acid
0.15 wt. % to 0.3 wt. %;
sodium chloride
0.50 wt. % to 0.8 wt. %;
surfactant
0.05 wt. % to 0.3 wt. %;
HCl or NaOH
to adjust pH; and
purified water
Q.S. to volume.
9. The antimicrobial ophthalmic composition of claim 8 additionally consisting of from about 0.001 wt. % to about 0.50 wt. % of sodium hyaluronate.
10. The antimicrobial ophthalmic composition of claim 6 wherein the ophthalmic composition additionally consisting of:
lubricant
0.05 wt. % to 0.30 wt. %;
sodium phosphate monobasic
0.10 wt. % to 0.25 wt. %;
sodium phosphate dibasic
0.10 wt. % to 0.40 wt. %;
sodium chloride
0.50 wt. % to 0.80 wt. %;
surfactant
0.05 wt. % to 0.30 wt. %;
HCl or NaOH
to adjust pH; and
purified water
Q.S. to volume.
11. The antimicrobial ophthalmic composition of claim 10 additionally consisting of from about 0.001 wt. % to about 0.50 wt. % sodium hyaluronate.
12. The antimicrobial ophthalmic composition of claim 1 wherein the composition is applied onto an eye for treating dryness of the eye.
13. The antimicrobial ophthalmic composition of claim 1 wherein the composition is applied onto an eye for treating an infection of an eye.
14. The antimicrobial ophthalmic composition of claim 13 wherein the infection is caused by bacterial keratitis.
15. The antimicrobial ophthalmic composition of claim 13 wherein the infection is caused by a virus.
16. The antimicrobial ophthalmic composition of claim 13 wherein the infection is caused by a fungus.
17. The antimicrobial ophthalmic composition of claim 1 wherein the composition is applied onto an eye for cleansing a contact lens in place on the eye.