Methods and compositions related to viral inhibition
View Patent ↗Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.
1. A compound comprising the structure
A-B-C
or a pharmaceutically acceptable salt or acid form thereof,
wherein A is a glycoside, aminoglycoside, or sugar, wherein B is a linker defined by -(L 1 ) v -, wherein v is independently 1-20,
wherein each (L 1 ) is independently O, N, S, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkoxy, aryl, heteroaryl, heterocyclyl,
wherein each (L1) is the same or different, and wherein C is a glycoside, aminoglycoside, sugar, Hoechst 33258, or Hoechst 33258 derived benzimidazoles.
2. The compound of claim 1 , wherein A is an aminoglycoside.
3. The compound of claim 2 , wherein A comprises neomycin.
4. The compound of claim 1 , wherein B comprises a backbone of less than 50.
5. A composition comprising the compound of claim 1 .
6. A composition comprising a complex comprising a composition of claim 5 and a virus.
7. A compound comprising the structure
A-B-C
or a pharmaceutically acceptable salt or acid form thereof,
wherein A is neomycin, B is —NHC(O)NH— and C is an aminoglycoside.
8. A compound comprising the structure
A-B-C
or a pharmaceutically acceptable salt or acid form thereof,
wherein A is a glycoside, aminoglycoside, or sugar, wherein B is a linker defined by -(L 1 ) v -, wherein v is independently 1-20,
wherein each (L 1 ) is independently O, N, S, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkoxy, aryl, heteroaryl, heterocyclyl,
wherein each (L1) is the same or different, and wherein C is Hoechst 33258, or a benzimidazole.
9. The compound of claim 8 wherein said benzimidazole is a Hoechst 33258 derived benzimidazole.