Reducing risk of contracting
View Patent ↗A method of treating a patient to reduce risk of developing Clostridium difficile -associated disease or reducing existing Clostridium difficile -associated disease in a mammalian subject involves administering to a mammalian subject an effective amount of a germination-inhibiting compound derived from taurocholate. Novel compounds of this class are also provided.
1. A method of reducing risk of developing Clostridium difficile -associated disease or reducing existing Clostridium difficile -associated disease in a mammalian subject, the method comprising administering to the mammalian subject an effective amount of a germination-inhibiting compound derived from taurocholate, wherein the compound derived from taurocholate is a compound conforming to:
wherein R 1 and R 2 are hydroxyl groups; R 3 is hydrogen; R 4 is oxygen; and R 5 is NH(m-(C 6 H 4 ))SO 3 H.
2. The method of claim 1 , further comprising a pharmaceutically acceptable salt.
3. The method of claim 1 , wherein the compound is a component of a pharmaceutical composition comprising a pharmaceutically acceptable salt.