Backside CMOS compatible BioFET with no plasma induced damage
The present disclosure provides a bio-field effect transistor (BioFET) device and methods of fabricating a BioFET and a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a gate structure disposed on a first surface of a substrate and an interface layer formed on a second surface of the substrate. The substrate is thinned from the second surface to expose a channel region before forming the interface layer.
1. A device, comprising:
a carrier substrate;
a first BioFET device attached to the carrier substrate, the first BioFET device including:
a gate structure on a first side of a semiconductor substrate;
a source region and a drain region in the semiconductor substrate adjacent to the gate structure;
a channel region interposing the source and drain regions and underlying the gate structure;
a sensing film directly on and covering at least a portion of the channel region on a second side of the semiconductor substrate; and
a microfluidic channel or microfluidic well disposed over the sensing film.
2. The device of claim 1 , further comprising:
an intrinsic dielectric film between the first BioFET device and a microfluidic structure containing the microfluidic channel or microfluidic well and surrounding the at least a portion of the channel region.
3. The device of claim 2 , wherein sidewalls of the intrinsic dielectric film has a straight profile.
4. The device of claim 1 , further comprising a coating for bio-molecule binding over the sensing film.
5. The device of claim 1 , wherein the sensing film is selected from the group consisting SiO 2 , Si 3 N 4 , Al 2 O 3 , TiO 2 , HfO 2 , Ta 2 O 5 , SnO, Sn 0 2 , Ba x Sr 1-31 x TiO3 and combinations thereof.
6. The device of claim 1 , wherein the first BioFET further comprises:
a multi-layer interconnect (MLI) disposed on the first side of the semiconductor substrate.
7. The device of claim 1 , further comprising:
a second BioFET connected to the first BioFET by the microfluidic channel; and
a third BioFET and a fourth BioFET connected to a second microfluidic channel, wherein the first, second, third and fourth BioFETs are disposed in an array configuration.
8. The device of claim 1 , wherein the microfluidic channel or microfluidic well comprises a layer of biocompatible material and wherein the sensing film extends under the layer of biocompatible material.
9. A device, comprising:
a Field Effect Transistor (FET) device on a substrate, wherein the FET device includes a gate structure formed on a first surface of the substrate and a channel region, the channel region having a top surface adjacent the gate structure and a bottom surface opposite the top surface;
an opening extending from a second surface of the substrate, opposite the first surface, through to the bottom surface of the channel region; and
a sensing film directly in the opening, the sensing film being on the bottom surface of the channel region and directly on at least a portion of the second surface of the substrate.
10. The device of claim 9 , further comprising:
a microfluidic chamber on the second surface of the substrate, wherein at least a portion of the sensing film is contained within the micro fluidic chamber.
11. The device of claim 10 , wherein the microfluidic chamber is selected from the group consisting of a microfluidic channel, a microfluidic well, and a combination thereof.
12. The device of claim 9 , further comprising a carrier substrate attached to the first surface of the substrate.
13. The device of claim 9 , further comprising an intrinsic dielectric layer on the second surface of the substrate.
14. The device of claim 13 , wherein the intrinsic dielectric layer forms a trench overlying the sensing film.
15. The device of claim 9 , further comprising a multi-layer interconnect (MLI) disposed on the first surface of the substrate.
16. The device of claim 9 , further comprising a receptor on the sensing film, wherein the receptor is selected from the group consisting of enzymes, antibodies, ligands, peptides, nucleotides, self-assembled molecules, and combinations thereof.
17. The device of claim 9 , further comprising a hydrophilic or hydrophobic coating on the sensing film.
18. A device comprising:
a FET device on a semiconductor substrate, the FET device including a gate structure formed on a first surface of the semiconductor substrate and a channel region in the semiconductor substrate below the gate structure, the channel region having a first surface proximate the gate and second surface distal the gate;
a carrier substrate attached to the first surface of the semiconductor substrate;
an opening extending through the semiconductor substrate and aligned with the second surface of the channel region;
a sensing film in the opening and contacting the second surface of the channel region and a second surface of the semiconductor substrate; and,
a microfluidic chamber over the sensing film.
19. The device of claim 18 , wherein the semiconductor substrate is a silicon-on-insulator (SOI) substrate.
20. The device of claim 18 , wherein the sensing film includes a receptor on the sensing film, wherein the receptor is selected from the group consisting of enzymes, antibodies, ligands, peptides, nucleotides, self-assembled molecules, and combinations thereof.