Beta sheet tapes ribbons in tissue engineering
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
1. A pair of self assembling complementary polypeptides (SACPs) that form tapes, ribbons, fibrils or fibres in a β-sheet tape-like substructure, when a first monomeric peptide is contacted or mixed with its complementary monomeric peptide and wherein each of the SACPs is 11 amino acid residues in length and wherein the SACPs comprise P 11 -13/14 (SEQ ID NOs: 2 and 3).
2. The SACPs of claim 1 , further comprising a bioactive peptide or a therapeutically active molecule.
3. The SAPs of claim 1 , wherein overall net change is −2.
4. A composition, comprising:
tapes, ribbons, fibrils or fibres, wherein each of the tapes, ribbons, fibrils or fibres has an antiparallel arrangement of SACPs in a β-sheet tape-like substructure, wherein the SACPs comprise P 11 -13/14 (SEQ ID NOs: 2 and 3).
5. The composition of claim 4 , wherein the composition comprises SACPs which form ribbons and/or fibrils immediately when a first monomeric peptide contacts a second complementary monomeric peptide.
6. The composition of claim 4 , wherein the SACPs further comprise a bioactive peptide or a therapeutically active molecule.
7. The composition of claim 4 , wherein the composition comprises fibrils, and wherein the fibrils are comprised in a network of fibrils interconnected at fibre-like junctions.
8. The composition of claim 4 , wherein the composition comprises a dental product.
9. The composition of claim 8 , wherein the dental product is a dental repair, dental treatment, or dental reconstruction product.
10. The composition of claim 4 , wherein the composition is in the form of a tissue engineering scaffold.
11. The composition according to claim 10 , wherein the scaffold is seeded with cells.
12. The composition of claim 4 , wherein the material comprises a skin treatment.
13. The composition of claim 4 , wherein the composition comprises a hair care product.
14. The composition of claim 4 , wherein the composition is part of a bioresponsive and biocompatible surface.
15. The composition of claim 4 , wherein the composition is a template for nucleation and growth of inorganic materials.
16. The composition of claim 4 , wherein the composition comprises a continuous filament yarn, staple, floc, cord, or fabric.