Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells
The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.
1. A method for eliciting an immune response against an antigen comprising contacting antigen presenting cells with a composition comprising an antibody-antigen complex having a Dendritic Cell Immunoreceptor (DCIR)-specific antibody, or DCIR-binding fragment thereof, attached to an antigen, wherein an immune response against the antigen is elicited.
2. The method of claim 1 , wherein DCIR-specific antibody or fragment thereof is bound to one half of a Cohesin/Dockerin pair.
3. The method of claim 1 , wherein DCIR-specific antibody or fragment thereof is bound to one half of a Cohesin/Dockerin pair and the antigen is bound to the complementary half of the Cohesin/Dockerin pair to form the complex.
4. The method of claim 1 , wherein the antigen is a bacterial, viral, fungal, or protozoan antigen.
5. The method of claim 1 , wherein the composition further comprises an adjuvant.
6. The method of claim 1 , wherein the antigen presenting cells are dendritic cells.
7. The method of claim 1 , wherein the antigen presenting cells are contacted with the composition by administering the composition to a patient.
8. The method of claim 1 , wherein the antigen is a Mycobacterium tuberculosis antigen.