IP Library › Granted Patent US 9,120,817
Granted Patent B2
US 9,120,817 · App. 14/513,265 · Granted Sep 1, 2015

Process for preparing (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′ ,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

Inventors: Steven N. Goodman (Research Triangle Park, NC); Huan Wang (Research Triangle Park, NC); Douglas Mans (Research Triangle Park, NC); Matthew Kowalski (Research Triangle Park, NC)
Assignee: VIIV HEALTHCARE COMPANY
C07D498/14C07D213/68C07D213/80
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Quick Facts
Patent No.
US 9,120,817
App. No.
14/513,265
Granted
Sep 1, 2015
Kind
B2
Abstract

The present invention relates to processes for the preparation of (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid by contacting a pyridinone carboxylic acid aldehyde with (3R)-3-amino-1-butanol.

Claims (3)

1. A process for the preparation of a compound of formula VIa:

comprising contacting a pyridinone carboxylic acid aldehyde of formula V

wherein R is alkyl, aryl, or benzyl, with (3R)-3-amino-1-butanol.

Continuity (3)
Division 13636237
Provisional Application 61316421 · Mar 23, 2010
Related Publication 20150057444A1 · Feb 26, 2015