Anti-cancer compositions and methods
Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
1. A method of modulating Akt dysregulation in a cell, comprising:
contacting the cell with an effective amount of an isoselenocyanate having the structural formula: R—(CH 2 ) n —N═C═Se, where n is an integer in the range of 1-8, inclusive, and where R is an aromatic group.
2. The method of claim 1 wherein contacting the cell decreases a component of an Akt signaling pathway selected from the group consisting of: an Akt1 signaling pathway; an Akt2 signaling pathway; an Akt3 signaling pathway; and a combination thereof.