Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile

1. A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin, said device comprising:

a substrate having a first surface and a second surface, wherein the first surface is configured to face the subject's skin;

an inlet port configured to be coupled to a supply line;

an outlet port configured to be coupled to an output line; and

a plurality of cooling elements positioned along a flow path between the inlet and outlet ports such that liquid from the inlet port flows through the cooling elements, each cooling element having a thermoelectric cooler, an interface member and an internal fluid chamber in thermal communication with interface members and a plurality of fluid ports in fluid communication with the internal fluid chamber, wherein the fluid ports are configured to allow liquid circulation through the internal fluid chamber, wherein the interface members have heat exchanging surfaces and wherein the plurality of cooling elements are attached to the substrate such that the heat exchanging surfaces of the interface members from a portion of the first surface of the substrate and the thermoelectric coolers are within the substrate.

2. The cooling device of claim 1 , wherein the liquid in communication with the internal fluid chamber is circulated through a device that chills the liquid.

3. The cooling device of claim 1 , wherein the internal fluid chamber is serpentine shaped.

4. The cooling device of claim 1 , wherein the cooling elements are fluidicly connected in series.

5. The cooling device of claim 1 , further comprising a thermally conductive coupling agent applied to an interface between the individual heat exchanging surfaces and the skin of the subject to increase thermal conductivity between the cooling device and the skin of the subject.

6. The cooling device of claim 1 , wherein the plurality of cooling elements are configured to reduce a temperature of a target region such that lipid-rich cells in the region are reduced while non-lipid-rich cells proximate to at least one of the heat exchanging surfaces are not significantly affected.

7. The cooling device of claim 1 , further comprising a sensing element proximate to at least one of the interface members.

8. The cooling device of claim 1 , further comprising:

a first temperature sensing element proximate to at least one of the interface members for detecting a temperature of a corresponding interface member; and

a second temperature sensing element proximate to at least one of the interface members for detecting a temperature of the skin of the subject.

9. The cooling device of claim 1 wherein the heat exchanging surfaces of the individual cooling elements are spaced apart from each other at the first surface of the substrate.

10. The cooling device of claim 1 , further comprising a processing unit programmed to cause the cooling elements to operate such that the cooling device cools the subcutaneous lipid-rich cells of the subject to a sufficiently low temperature for 10 minutes so as to selectively disrupt the lipid-rich cells.

11. The cooling device of claim 10 wherein the processing unit is programmed to cause the cooling elements to operate such that the cooling elements are cooled to a temperature less than −5° for 15 minutes.

12. A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin, the cooling device comprising:

a plurality of cooling elements rotatable relative to each other, each cooling element including

a thermoelectric cooler, and

an internal fluid chamber configured to hold liquid coolant in thermal communication with the thermoelectric cooler;

an inlet port configured to be coupled to a supply line such that liquid coolant from the supply line flows into and through the internal fluid chambers;

an outlet port configured to be coupled to an output line such that liquid coolant that has passed through the internal fluid chambers flows through the outlet port and into the output line;

a processing unit programmed to cause the cooling elements to operate to cool the subcutaneous lipid-rich cells of the subject to a sufficiently low temperature so as to selectively disrupt the subcutaneous lipid-rich cells; and

a flexible substrate coupled to the cooling elements, wherein the flexible substrate is configured to face the subject's skin such that the plurality of cooling elements are in thermal communication with the subcutaneous lipid-rich cells.

13. The cooling device of claim 12 wherein the processing unit is programmed to cause the cooling elements to cool the subcutaneous lipid-rich cells of the subject such that the subcutaneous lipid-rich cells are at a temperature that selectively disrupts lipid-rich cells for at least 10 minutes.

14. The cooling device of claim 12 wherein the processing unit is programmed to cause the cooling elements to operate to cool to the subcutaneous lipid-rich cells to less than −5° for 15 minutes.