Feedback system for integrating interventional planning and navigation

1. A system for ablation treatment of tissue, comprising:

an ablation probe ( 6 ) for treating a tissue of interest with at least one of RF ablation, cryo-ablation, microwave ablation, ultrasound ablation, or other thermal or non-thermal ablation;

a planning component ( 1 ) for calculating a three-dimensional treatment plan including a plurality of desired ablation probe placement positions and orientations and a plurality of estimated ablation volumes to achieve a composite ablation volume that will treat an entire planned target volume (PTV);

a navigation component ( 2 ) comprising a tracking system ( 5 ) for spatially tracking at least one of the ablation probe and an imaging device and providing treatment instructions to an operator based on the three-dimensional treatment plan;

an imaging system ( 4 ) for obtaining planning and treatment images of the tissue to be treated; and

a feedback component ( 3 ) for determining actual probe position and orientation using the navigation component or imaging component, and for determining actual ablation volume based on treatment images provided by the imaging component ( 4 ), and feeding the actual probe position and orientation and actual ablation volume during treatment to the planning component ( 1 ),

wherein the planning component ( 1 ) determines a treatment iteration based on the treatment plan, the actual probe position and orientation and actual ablation volume, the treatment iteration including at least one of a desired next probe position and orientation and a desired next ablation volume,

wherein the navigation component ( 2 ) provides revised treatment instructions to the operator based on the treatment iteration until treatment is completed according to the desired planned target volume,

characterized in the feedback component ( 3 ) being configured to obtain information including imaging feedback and tracking feedback about the actual probe location, and provide the information including both the imaging feedback and tracking feedback to the planning component ( 1 ) to update the three-dimensional treatment plan,

wherein the planning component ( 1 ) receives the information and updates the plan by subtracting a measured ablation size and shape at a measured ablation position from an initially segmented planned target volume, and computes a new plan for a remaining part of the planned target volume.

2. The system according to claim 1 , wherein the imaging component ( 4 ) provides at least one of ultrasound, CT, MR imaging, ultrasound elastography, and Doppler ultrasound, and wherein the navigation component provides at least one of spatial tracking coordinates of the ablation probe and imaging, based on at least one of electromagnetic (EMP), optical, acoustic, and magnetic tracking sensors.

3. The system according to claim 1 , further comprising a user interface for displaying the treatment iteration instructions from the navigation component ( 2 ) for access by a human operator.

4. The system according to claim 1 , wherein the feedback component ( 3 ) further calculates at least one of local micro-vascular perfusion and macro-vascular blood flow parameters near the ablation site and provides the information to the planning component ( 1 ) for incorporation into the treatment iteration.

5. The system according to claim 1 , wherein the feedback component ( 3 ) registers treatment images with planning images to calculate at least one of the actual probe position and orientation and tumor position and orientation, and uses the information to update the three-dimensional treatment plan; and

wherein the planning component ( 1 ) utilizes center positions of individual ablations for calculating the three-dimensional treatment plan.

6. The system according to claim 1 , wherein the feedback component ( 3 ) obtains imaging feedback and tracking feedback about actual probe location, and uses the information to update and improve registration between the imaging system and the tracking system.

7. A method of ablation therapy of tissue, comprising:

calculating, in a planning component, a three-dimensional treatment plan ( 20 ) for a tissue volume of interest including a plurality of desired ablation probe placement positions and orientations and a plurality of estimated ablation volumes to achieve a desired planned target volume that will treat the entire tissue volume of interest;

providing treatment instructions ( 14 ) to an operator based on the three-dimensional treatment plan;

treating the tissue volume of interest with at least one of RF ablation, cryo-ablation, microwave ablation, ultrasound ablation, and other thermal or non-thermal ablation;

obtaining planning ( 10 ) images and treatment images, from an imaging system, of the tissue volume to be treated;

determining, in a feedback component, actual probe position and orientation and actual ablation volume ( 30 ) based on the treatment images; and

calculating a treatment iteration ( 32 ), in the planning component, based on the treatment plan, the actual probe position and orientation and actual ablation volume, the treatment iteration including at least one of a desired next probe position and a desired next ablation volume, and

providing revised treatment instructions to the operator based on the treatment iteration and continuing iterative treatment until treatment is completed according to the desired planned target volume, wherein

the planning component ( 1 ) receives the information and updates the plan by subtracting a measured ablation size and shape at a measured ablation position from an initially segmented planned target volume, and computes a new plan for a remaining part of the planned target volume.

8. The method according to claim 7 , wherein the imaging component provides at least one of ultrasound, CT, MR imaging, ultrasound elastography, and Doppler ultrasound, and wherein the navigation component provides at least one of spatial tracking coordinates of the therapy probe and imaging based on at least one of electromagnetic (EM), optical, acoustic, and magnetic sensors.

9. The method according to claim 7 , wherein the treatment is carried out by a human operator accessing at least one of the treatment plan and the treatment iteration instruction from a user interface.

10. The method according to claim 7 , wherein at least one of local micro-vascular perfusion and macro-vascular blood flow parameters near the ablation site are calculated and this information is incorporated into the treatment iteration.

11. The method according to claim 7 , wherein the treatment images are registered with planning images to calculate at least one of the actual probe position and orientation and tumor position and orientation, and to use the information to update the three dimensional treatment plan, and

wherein the planning component ( 1 ) utilizes center positions of individual ablations for calculating the three-dimensional treatment plan.

12. The method according to claim 7 , wherein treatment images showing the actual ablation probe location and tracking data representing the actual probe position are used to update the registration between the imaging system and the tracking system.

13. A control system for ablation treatment of tissue, comprising:

a planning component ( 1 ) for calculating a three-dimensional treatment plan including a plurality of desired ablation probe placement positions and orientations and a plurality of estimated ablation volumes to achieve a desired planning target volume that will treat an entire tissue volume of interest;

a navigation component ( 2 ) comprising a tracking system ( 5 ) for spatially tracking at least one of the ablation probe and an imaging device;

an imaging system ( 4 ) for obtaining treatment images of the tissue to be treated; and

a feedback component ( 3 ) for calculating actual probe position and orientation of a probe and actual ablation volume based on treatment images provided by the imaging component, and feeding the actual probe position and orientation and actual ablation volume during treatment to the planning component,

wherein the planning component ( 1 ) maps the actual probe location and actual ablation volume to the three-dimensional plan and calculates a treatment iteration based on the treatment plan, the actual probe position and orientation and actual ablation volume, the treatment iteration including at least one of a desired next probe position and orientation and a desired next ablation volume,

characterized in that the feedback component ( 3 ) obtains information including imaging feedback and tracking feedback about the actual probe location, and provides the information including both the imaging feedback and tracking feedback to the planning system to update the three-dimensional treatment plan, and

wherein the planning component ( 1 ) receives the information and updates the plan by subtracting a measured ablation size and shape at a measured ablation position from an initially segmented planned target volume, and computes a new plan for a remaining part of the planned target volume, and

wherein the planning component ( 1 ) receives the information and updates the plan by subtracting a measured ablation size and shape at a measured ablation position from an initially segmented planned target volume, and computes a new plan for a remaining part of the planned target volume.

14. The control system according to claim 13 , wherein the imaging component ( 4 ) provides at least one of ultrasound, CT, MR imaging, ultrasound elastography, and Doppler ultrasound, and wherein the navigation component provides at least one of electromagnetic (EM), optical, acoustic, and magnetic sensors.

15. The control system according to claim 13 , wherein the control system delivers the next treatment ablation according to the calculated treatment iteration by at least one of moving the ablation probe to the desired next probe position and ablating the next desired ablation volume.

16. The control system according to claim 13 , wherein the feedback component ( 3 ) further calculates at least one local micro-vascular perfusion and macro-vascular blood flow parameters near the ablation site and provides this information to the planning component for incorporation into the treatment iteration.

17. The control system according to claim 13 , wherein the feedback component ( 3 ) registers treatment images with planning images to calculate at least one of the actual probe position and orientation and tumor position and orientation, and uses the information to update the three-dimensional treatment plan; and

wherein the planning component ( 1 ) utilizes center positions of individual ablations for calculating the three-dimensional treatment plan.

18. The control system according to claim 13 , wherein the feedback component ( 3 ) obtains imaging feedback and tracking feedback about the actual probe location and uses the information to improve registration between the imaging system ( 4 ) and tracking system ( 5 ).

19. The control system according to claim 14 , wherein the imaging component ( 4 ) utilizes a contrast medium.

20. The control system according to claim 13 , wherein the planning component ( 1 ) utilizes center positions of individual ablations for calculating the three-dimensional treatment plan.