Topical antiviral formulations
The disclosure provides antiviral pharmaceutical compositions comprising one or more antiviral compounds and 2-deoxy-D-glucose in the form of lip-balms, creams and ointments. A specific embodiment discloses a lip-balm composition comprising acyclovir and 2-deoxy-D-glucose.
1. A topical pharmaceutical composition comprising a therapeutically effective amount of an antiviral compound selected from one or more of the group consisting of acyclovir, or a pharmaceutically acceptable salt or hydrate thereof; and
a therapeutically effective amount of 2-deoxy-D-glucose.
2. The composition of claim 1 , wherein the antiviral compound is acyclovir.
3. The composition of claim 1 in a form selected from a lip-balm, stick, cream or ointment.
4. The composition of claim 3 in a lip-balm form.
5. The composition of claim 4 , further comprising one or more polyethylene glycols.
6. The composition of claim 5 , further comprising one or more sweeteners or flavorings.
7. The composition of claim 6 , wherein the sweetener is stevioside.
8. The composition of claim 6 , wherein the flavoring is spearmint oil.
9. The composition of claim 2 , wherein the composition comprises from about 3 wt % to about 7 wt % of acyclovir and from about 0.1 wt % to about 5 wt % of 2-deoxy-D-glucose.
10. The composition of claim 9 , wherein the composition comprises about 5 wt % of acyclovir and about 0.2 wt % of 2-deoxy-D-glucose.
11. A method of treating a herpes viral infection of a patient in need thereof comprising topically administering a pharmaceutical composition comprising a therapeutically effective amount of an antiviral compound selected from the group consisting of acyclovir, or a pharmaceutically acceptable salt thereof; and a therapeutically effective amount of 2-deoxy-D-glucose.
12. The method of claim 11 , wherein the antiviral compound is acyclovir.
13. The method of claim 11 , wherein the composition is in a form selected from a lip-balm, stick, cream or ointment.
14. The method of claim 13 , wherein the composition is in a lip-balm form.
15. The method of claim 12 , wherein the composition comprises from about 3 wt % to about 7 wt % of acyclovir and from about 0.1 wt % to about 5 wt % of 2-deoxy-D-glucose.
16. The method of claim 15 , wherein the topical comprises about 5 wt % of acyclovir and about 0.2 wt % of 2-deoxy-D-glucose.
17. The method of claim 11 , wherein the treatment is for latent infection of herpes simplex type 1 infection.
18. The method of claim 11 , wherein the treatment is for latent infection of herpes simplex type 2 infection.
19. The method of claim 11 , wherein the infection is an orofacial herpes infection.
20. A method of reducing the duration of a herpes viral infection outbreak in a mammal in need thereof comprising topically administering a pharmaceutical composition comprising a therapeutically effective amount of an antiviral compound selected from the group consisting of acyclovir, or a pharmaceutically acceptable salt thereof; and a therapeutically effective amount of 2-deoxy-D-glucose.
21. The method of claim 20 , wherein the antiviral compound is acyclovir.
22. The method of claim 20 , wherein the treatment is for latent infection of herpes simplex type 1 infection.
23. The method of claim 20 , wherein the treatment is for latent infection of herpes simplex type 2 infection.
24. The method of claim 20 , wherein the infection is an orofacial herpes infection.