APLs for treating arthritis
One embodiment of a therapeutic composition comprises one or more APLs, e.g., APL A12, for treating diseases or disorders related to arthritis, including rheumatoid arthritis. Another embodiment includes a method of inducing a Th2-type cytokine secretion profile in a mammal, including administering a therapeutic amount of A12 analog peptide. Another embodiment includes a method for generating functional T regulatory cells, the method including administering a therapeutic amount of APL A12 to a RA patient.
1. A therapeutic composition comprising an altered peptide ligand (APL) for treatment or inhibition of Rheumatoid Arthritis (RA) in patients in need thereof, wherein the APL comprises the amino acid sequence LGPKGQTGEBGIAGAKGDQGPKGEBGPA (SEQ ID NO: 2).
2. The therapeutic composition of claim 1 in injectable form.
3. The therapeutic composition of claim 1 in oral form.
4. The therapeutic composition of claim 1 in a dose range effective to treat or inhibit RA in patients in need thereof.
5. The therapeutic composition of claim 4 , wherein the dose range is from about 30 μg/day to about 1,000 μg/day.
6. The therapeutic composition of claim 5 , wherein the dose is about 30 μg/day.
7. The therapeutic composition of claim 5 , wherein the dose is about 300 μg/day.
8. The therapeutic composition of claim 5 , wherein the dose is about 1,000 μg/day.
9. The therapeutic composition of claim 1 , further comprising one or more compounds selected from carriers, solvents, and excipient.
10. A method of treating RA, comprising administering to a subject in need thereof the therapeutic composition of claim 2 .
11. The composition of claim 1 , further comprising a carbohydrate.
12. The method of claim 10 , wherein administering is performed over a period of time.
13. The method of claim 12 , wherein administering comprises one or more administrations within one day.
14. The method of claim 12 , wherein administering comprises one or more administrations over a period of one or more days.
15. A method of inducing a T helper cell type 2 (Th2-type) cytokine secretion profile in a mammal, comprising administering a therapeutic amount of a peptide comprising SEQ ID NO: 2.
16. A method of generating functional T regulatory cells, the method comprising administering a therapeutic amount of a peptide sequence comprising SEQ ID NO: 2 to a RA patient.