Derivative of [(3-hydroxy-4-pyron-2-yl)-methyl]-amine and use thereof as anti-neoplastic drugs
The present invention relates to compounds having general formula (I), i.e. poly-alkyl-bis-maltolic molecules and in particular to derivates of [(3-hydroxy-4-pyron-2-yl)methyl]-amine and pharmaceutically acceptable salts thereof, and to the use thereof as anti-neoplastic drugs, in particular, for the preparation of a medicament for the treatment of neoplastic diseases.
1. Compounds having Formula I:
wherein:
X 1 , X 2 , X 3 , X 4 =NR 3 , O
R 3 =H, C m H 2m+1 , m=1, 2, 3, 4, 5, 6
n, f, 1, v=0,1
j, k, q, t, z=1, 2
R 1 , R 2 =C m H 2m+1 , m=1, 2, 3, 4, 5, 6
or alternatively form a ring and have the following meaning:
wherein:
Y=NR 3 , O
R 3 =H, C m H 2m+1 , m=1, 2, 3, 4, 5, 6
p=0, 1, 2, 3, 4;
s=0, 1, 2
r=1,2
and pharmaceutically acceptable salts thereof.
2. A method of preparing a medicament, comprising:
combining a predetermined dosage of a compound according to claim 1 with at least one of a pharmaceutically acceptable carrier, stabiliser, diluent, excipient and combinations thereof.
3. A method of treating a patient, comprising:
administering an antibiotic comprising a predetermined concentration of a compound according to claim 1 .
4. A method of treating a primary tumour, the method comprising:
administering a predetermined dosage of a compound according to claim 1 to the primary tumour to impair cell cycle and programmed cell death;
wherein the primary tumour is at least one of rhabdomyosarcoma, leukaemias and lymphomas.