Diabetes therapy
The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.
1. A method for treating type 2 diabetes in a patient in need thereof, the method comprising subcutaneously or transdermally administering linagliptin and basal insulin, and, optionally, administering a further therapeutic agent selected from metformin and pioglitazone, wherein the administration of linagliptin and basal insulin is carried out separately, sequentially, or simultaneously.
2. The method of claim 1 wherein the long-acting basal insulin is insulin detemir, insulin glargine, or insulin degludec.
3. A method of treating type 2 diabetes, the method comprising subcutaneously or transdermally administering linagliptin once daily, every other day, thrice weekly, twice weekly, or once weekly.
4. The method according to claim 1 , wherein the linagliptin is administered subcutaneously.
5. The method according to claim 1 , wherein the linagliptin is administered transdermally.
6. The method according to claim 1 , wherein the basal insulin is administered subcutaneously.
7. The method according to claim 1 , wherein the basal insulin is administered transdermally.
8. The method according to claim 1 , wherein both the basal insulin and linagliptin are administered subcutaneously.