N-acetyl-DL-leucine, neuroprotective and retinoprotective medicament
View Patent ↗The invention relates to a medicament, the active principle of which is a leucine and, for example, a N-ACETYL-DL-LEUCINE. It can be applied to the prevention and/or treatment of eye diseases or disorders and especially of hereditary dystrophies of the retina, glaucomatous neuropathy, glaucoma, macular degeneration, myopia, presbyopia, hypermetropia, astigmatism, all the ophtalmologic diseases or disorders inducing a decrease of visual function and/or age-related physiological vision decline.
1. A method for treating one or several ophthalmologic diseases, which are diseases comprising a retina and/or optic nerve damage and are selected from the group of hereditary dystrophies of the retina, comprising: pigmentosa retinopathy and stargardt's disease, in an animal in need thereof consisting of administering to said animal a medicament consisting essentially of a N-acetyl-DL-leucine or one of its pharmaceutically acceptable salts and an opthamologically pharmaceutically acceptable vehicle selected from the group consisting of distilled water, deionized water, saline solution, phosphate buffered saline solution, and physiological serum.
2. The method according to claim 1 , wherein said pharmaceutically acceptable vehicle in said medicament can be administered in an oral or topical form.
3. The method according to claim 1 , wherein said medicament is in a form for topical administration.
4. The method according to claim 1 , wherein said medicament is in the form of eye drops.
5. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are glaucomatous neuropathy and/or glaucoma.
6. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are age-related macular degeneration and/or myopic macular degeneration.
7. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are myopia.
8. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are presbyopia.
9. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are refractive defects selected from the group of astigmatism and hypermetropia.
10. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are hemeralopia.
11. The method according to claim 1 , wherein said one or several of the neuroprotective and/or retinoprotective ophthalmologic diseases are diabetic retinopathy.
12. The method according to claim 1 , wherein said medicament is administered to a human in need thereof topically to the eye, in a concentration of 0.5 to 5%, and/or orally, in an amount of 0.5 to 5 g/day or 1 to 3 g/day.
13. A method for maintaining or improving vision in an animal suffering from a disease comprising a retina and/or optic nerve damage and selected from the group of hereditary dystrophies of the retina, comprising: pigmentosa retinopathy and stargardt's disease, said method consisting of administering to said animal a medicament consisting essentially of a N-acetyl-DL-leucine or one of its pharmaceutically acceptable salts and an opthamologically pharmaceutically acceptable vehicle selected from the group consisting of distilled water, deionized water, saline solution, phosphate buffered saline solution, and physiological serum.