Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.
1. A method of attenuating neuronal damage in a human subject suffering from traumatic brain injury, the method comprising:
administering a therapeutically effective amount of a pharmaceutical composition comprising at least one of CSF-1 and Interleukin-34 to said human subject within six hours following said traumatic brain injury to attenuate neuronal damage in said human subject.
2. The method of claim 1 , wherein said pharmaceutical composition comprises CSF-1.
3. The method of claim 1 , wherein said pharmaceutical composition comprises Interleukin-34.
4. The method of claim 1 , where the administering is systemic or local.
5. A method of stimulating neuronal repair in a human subject suffering from traumatic brain injury, the method comprising:
administering a therapeutically effective amount of a pharmaceutical composition comprising at least one of CSF-1 and Interleukin-34 to said human subject within six hours following said traumatic brain to stimulate neuronal repair in said human subject.
6. The method of claim 5 , wherein said pharmaceutical composition comprises CSF-1.
7. The method of claim 5 , wherein said pharmaceutical composition comprises Interleukin-34.
8. The method of claim 5 , where the administering is systemic or local.
9. A method of attenuating neuronal damage in a mammalian subject suffering from traumatic brain injury, the method comprising:
administering a therapeutically effective amount of a pharmaceutical composition comprising CSF-1 to said mammalian subject within six hours following said traumatic brain injury to attenuate neuronal damage in said mammalian subject.