Preparation and pharmaceuticals of biphenyl benzamide-derived derivatives
The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II and the synthesis and the application thereof.
1. A biphenyl benzamide-derived derivatives, which structure is selected from formula I:
wherein said R1, R2, R3 and R4 of the formula I are selected from the group consisting of H, halogen, CN, CH and OCH3.
2. A pharmaceutical composition of biphenyl benzamide-derived derivatives, which comprises:
(a) a structure selected from formula I:
and
(b) a pharmaceutical acceptable salt and carrier of the biphenyl benzamide-derived derivatives;
wherein said R1, R2, R3 and R4 of the formula I are selected from the group consisting of H, halogen, CN, CH and OCH3.
3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical acceptable carrier is an excipient, diluents, thickeners, filler, binder, disintegrants, lubricant, oil or non-oil base, surfactant, suspending agent, gelling agent, adjuvant, anti-corrosive agent, anti-oxidant, stabilizer, coloring agent or flavor.
4. The pharmaceutical composition of claim 2 , wherein the salt is a physiologically acceptable salt of an inorganic acid, inorganic base, organic acid or organic base.
5. The pharmaceutical composition of claim 2 , wherein said composition is a powder, granule, liquid, gel or cream.
6. The pharmaceutical composition of claim 2 wherein said composition is administered through an oral, transdermal, injection, or inhalational manner.
7. A method for synthesis of benzamide-derived derivatives, wherein a compound of formula I is synthesized by difunisal:
8. The method of claim 7 , wherein the compound of formula I is synthesized by amine, tetrahydrofuran and an intermediate compound which is synthesized by difunisal, tetrahydrofuran and thionyl chloride.
9. A method of treating osteoporosis or osteoarthritis with an anti-inflammatory agent of biphenyl benzamide-derived derivatives comprising:
administering an effective amount of the anti-inflammatory agent of biphenyl benzamide-derived derivatives to a subject in need thereof,
wherein the anti-inflammatory agent of biphenyl benzamide-derived derivatives comprises a structure of formula I:
wherein said R1, R2, R3 and R4 of the formula II are selected from the group consisting of H, halogen, CN, CH3 and OCH3.