AAV capsid proteins for nucleic acid transfer
View Patent ↗Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided.
1. A nucleotide sequence encoding a capsid protein, wherein the capsid protein has at least 99% sequence identity to SEQ ID NO: 31.
2. The nucleotide sequence of claim 1 , wherein said capsid protein sequence is encoded by the nucleotide sequence of SEQ ID NO: 4 or SEQ ID NO: 19.
3. A viral particle comprising the nucleotide sequence of claim 1 .
4. A plasmid comprising the nucleotide sequence of claim 1 .
5. A recombinant AAV particle, comprising a capsid protein with at least 99% sequence identity to SEQ ID NO: 31.
6. The nucleotide sequence of claim 1 , wherein the capsid protein is identical to SEQ ID NO: 31.
7. A viral particle comprising the nucleotide sequence of claim 6 .
8. A plasmid comprising the nucleotide sequence of claim 6 .
9. The recombinant AAV particle of claim 5 , wherein the capsid protein is identical to SEQ ID NO: 31.
10. A capsid protein with at least 99% sequence identity to SEQ ID NO: 31.
11. A capsid protein identical to SEQ ID NO: 31.